Synthesis, molecular docking and heme detoxification of pyrano[2,3-c]pyrazoleaminoquinoline hybrids as potential antimalarial agents

• Main Authors: Lekkala Ravindar,, Ng, Yan Hong, Khairul Azreena Bakar,, Ahmad Fadhlurrahman Ahmad Hidayat,, Shevin Rizal Feroz,, Raheem, Saki, Siti Aishah Hasbullah,, Nurul Izzaty Hassan,
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2024
• Online Access: http://journalarticle.ukm.my/24364/1/SL%2018.pdf; http://journalarticle.ukm.my/24364/; https://www.ukm.my/jsm/english_journals/vol53num8_2024/contentsVol53num8_2024.html

Malaria, an infectious disease that spreads widely and can kill people, is still a problem for global health. This study adds to the list of possible solutions by making a group of new pyrano[2,3-c]pyrazole-aminoquinoline hybrids. Here, five novel hybrids were synthesized by covalently linking the s...