Determination of non-organ specific autoantibodies in patients with chronic hepatitis C and association with HLA DRΒ1 (*04) allele
The regulation of immune mechanisms is controlled by major histocompatibility complex/human leukocyte antigen (MHC/HLA). Polymorphisms of the HLA region have an impact on susceptibility to complex infectious and autoimmune diseases. The present study was carried out to determine the frequencies of A...
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Universiti Kebangsaan Malaysia
2022
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my-ukm.journal.210262023-02-03T08:09:34Z http://journalarticle.ukm.my/21026/ Determination of non-organ specific autoantibodies in patients with chronic hepatitis C and association with HLA DRΒ1 (*04) allele Ayub, Fatima Tahir, Romeeza Kashif, Muhammad Javaid, Khursheed Shahzad, Faheem Jahan, Shah Afzal, Nadeem The regulation of immune mechanisms is controlled by major histocompatibility complex/human leukocyte antigen (MHC/HLA). Polymorphisms of the HLA region have an impact on susceptibility to complex infectious and autoimmune diseases. The present study was carried out to determine the frequencies of ASMA, AMA, ANA, dsDNA, and anti-LKM-1 auto-antibodies in hepatitis C patients and to determine their association with the HLA DRβ1 (*04) locus. It was a cross-sectional, analytical study, and 86 patients with chronic HCV were recruited. The presence of auto-antibodies (ASMA, AMA, ANA, dsDNA, and anti-LKM-1) was determined by indirect immunofluorescence and ELISA, while the HLA DRβ1 (*04) allele was assessed by sequence-specific conventional PCR. ANA was detected in 41%, ASMA in 17.4%, AMA in 7%, LKM-1 in 5.8% dsDNA in 4.6% of CHC patients while HLA-DRβ1 (*04) was present in 3.5% of patients, but this was not significantly associated with these auto-antibodies. Universiti Kebangsaan Malaysia 2022 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/21026/1/SBL%2017.pdf Ayub, Fatima and Tahir, Romeeza and Kashif, Muhammad and Javaid, Khursheed and Shahzad, Faheem and Jahan, Shah and Afzal, Nadeem (2022) Determination of non-organ specific autoantibodies in patients with chronic hepatitis C and association with HLA DRΒ1 (*04) allele. Sains Malaysiana, 51 (11). ISSN 0126-6039 http://www.ukm.my/jsm/index.html |
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The regulation of immune mechanisms is controlled by major histocompatibility complex/human leukocyte antigen (MHC/HLA). Polymorphisms of the HLA region have an impact on susceptibility to complex infectious and autoimmune diseases. The present study was carried out to determine the frequencies of ASMA, AMA, ANA, dsDNA, and anti-LKM-1 auto-antibodies in hepatitis C patients and to determine their association with the HLA DRβ1 (*04) locus. It was a cross-sectional, analytical study, and 86 patients with chronic HCV were recruited. The presence of auto-antibodies (ASMA, AMA, ANA, dsDNA, and anti-LKM-1) was determined by indirect immunofluorescence and ELISA, while the HLA DRβ1 (*04) allele was assessed by sequence-specific conventional PCR. ANA was detected in 41%, ASMA in 17.4%, AMA in 7%, LKM-1 in 5.8% dsDNA in 4.6% of CHC patients while HLA-DRβ1 (*04) was present in 3.5% of patients, but this was not significantly associated with these auto-antibodies. |
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Ayub, Fatima Tahir, Romeeza Kashif, Muhammad Javaid, Khursheed Shahzad, Faheem Jahan, Shah Afzal, Nadeem |
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Ayub, Fatima Tahir, Romeeza Kashif, Muhammad Javaid, Khursheed Shahzad, Faheem Jahan, Shah Afzal, Nadeem Determination of non-organ specific autoantibodies in patients with chronic hepatitis C and association with HLA DRΒ1 (*04) allele |
author_facet |
Ayub, Fatima Tahir, Romeeza Kashif, Muhammad Javaid, Khursheed Shahzad, Faheem Jahan, Shah Afzal, Nadeem |
author_sort |
Ayub, Fatima |
title |
Determination of non-organ specific autoantibodies in patients with chronic hepatitis C and association with HLA DRΒ1 (*04) allele |
title_short |
Determination of non-organ specific autoantibodies in patients with chronic hepatitis C and association with HLA DRΒ1 (*04) allele |
title_full |
Determination of non-organ specific autoantibodies in patients with chronic hepatitis C and association with HLA DRΒ1 (*04) allele |
title_fullStr |
Determination of non-organ specific autoantibodies in patients with chronic hepatitis C and association with HLA DRΒ1 (*04) allele |
title_full_unstemmed |
Determination of non-organ specific autoantibodies in patients with chronic hepatitis C and association with HLA DRΒ1 (*04) allele |
title_sort |
determination of non-organ specific autoantibodies in patients with chronic hepatitis c and association with hla drβ1 (*04) allele |
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Universiti Kebangsaan Malaysia |
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2022 |
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http://journalarticle.ukm.my/21026/1/SBL%2017.pdf http://journalarticle.ukm.my/21026/ http://www.ukm.my/jsm/index.html |
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