HLA-DPB1*04:01 allele is associated with non-obstructive azoospermia in Japanese patients

• Main Authors: Timothy Adrian, Jinam, Hirofumi, Nakaoka, Kazuyoshi, Hosomichi, Shigeki, Mitsunaga, Hiroyuki, Okada, Atsushi, Tanaka, Kenichi, Tanaka, Ituro, Inoue
• Format: Article
• Language: English
• Published: Springer Nature 2013
• Subjects: QH426 Genetics
• Online Access: http://ir.unimas.my/id/eprint/42223/1/HLA.pdf; http://ir.unimas.my/id/eprint/42223/; https://link.springer.com/article/10.1007/s00439-013-1347-7

Azoospermia is defined by absence of sperm in the semen and can either be caused by obstruction of the seminal tract (obstructive azoospermia) or by defects in spermatogenesis (non-obstructive azoospermia, NOA). Previous studies reported that specific alleles and single nucleotide polymorphisms...