Squamous cell carcinoma of the tongue in a patient with rothmund-thomson syndrome (Recq4 Mutation) - intolerance to radiotherapy

• Main Authors: Hamidah A,, Mazlina M,, Zarina AL,, Muhaizan WM,, Fuad I,, Jamal R,
• Format: Article
• Language: English
• Published: Penerbit UKM 2009
• Online Access: http://journalarticle.ukm.my/1952/1/04-4%282%29_~_MS_085_%2864-75%29.pdf; http://journalarticle.ukm.my/1952/; http://www.ppukm.ukm.my/ukmmcjournal/index.php

We report a case of squamous cell carcinoma of the base of the tongue in a 27 years old patient with Rothmund-Thomson syndrome (RTS). An abnormal DNA repair mechanism in some RTS patients predispose them to malignancy and influence the tolerance to radiotherapy.