Synthesis, characterization and antioxidant activity of 3-(2-Amino-1,3-Selenazol-4-yl)-2H-Chromen-2-Ones derivatives

• Main Authors: Nurul Zawani Alias,, Nurul Izzaty Hassan,, Zaini Yusoff,, Sharizal Hasan,, Wan Yaacob Wan Ahmad,
• Format: Article
• Language: English
• Published: Penerbit Universiti Kebangsaan Malaysia 2018
• Online Access: http://journalarticle.ukm.my/12014/1/UKM%20SAINSMalaysiana%2047%2802%29Feb%202018%2017.pdf; http://journalarticle.ukm.my/12014/; http://www.ukm.my/jsm/english_journals/vol47num2_2018/contentsVol47num2_2018.html

Selenocompounds have been widely synthesized for their potential in pharmacology. Ebselen, a selenazole oxide, is a glutathione peroxidase mimic which is known to possess high antioxidant activity. Four derivatives of 3-(2-amino-1,3- selenazol-4-yl)-2H-chromen-2-ones were synthesized by reacting 3...