FIXEL BASED ANALYSIS: AGE AND GENDER-RELATED EFFECTS OF NORMAL HEALTHY AGING ON WHITE MATTER FIBRE

White matter fibre bundles change dynamically over the adulthood lifespan. These changes could be driven by the changes in axonal diameter, axonal density, and myelin content. In this study, the objective is to develop a pipeline to investigate the changes in fibre bundle characteristics related to...

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Main Author: CHOY, SHAO WEI
Format: Thesis
Language:English
Published: 2021
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Online Access:http://utpedia.utp.edu.my/id/eprint/20508/1/ChoyShaoWei_18001859.pdf
http://utpedia.utp.edu.my/id/eprint/20508/
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spelling oai:utpedia.utp.edu.my:205082024-07-25T09:11:08Z http://utpedia.utp.edu.my/id/eprint/20508/ FIXEL BASED ANALYSIS: AGE AND GENDER-RELATED EFFECTS OF NORMAL HEALTHY AGING ON WHITE MATTER FIBRE CHOY, SHAO WEI TK Electrical engineering. Electronics Nuclear engineering White matter fibre bundles change dynamically over the adulthood lifespan. These changes could be driven by the changes in axonal diameter, axonal density, and myelin content. In this study, the objective is to develop a pipeline to investigate the changes in fibre bundle characteristics related to a healthy ageing study by using the latest diffusion imaging technology. Limited studies had investigated alterations in fibre bundle characteristics with age, particularly in the range spanning early to late adulthood. We expanded the analysis by applying the fixel-based analysis framework using open-source pipelines with computing acceleration to examine the microscopic and macroscopic white matter changes throughout the adult lifespan. Additional processing steps were added to process low quality clinical data. By using the single shell (b=1000s/mm2) diffusion-weighted images and high-resolution T1 from a cohort of 293 healthy volunteers (89 males/204 females) ages 21 to 86 years old, we performed fixel based analysis to analyse age-related changes in microscopic fibre density and the macroscopic morphology, fibre cross-section. Whole-brain fixel based analysis was performed using the connectivity-based fixel enhancement technique to analyse the cross-sectional changes in fibre density and fibre cross-section measurements. The tract-level analysis was also performed on 11 major fibre tracts to evaluate the changes in white matter associated with age and gender. 2021-08 Thesis NonPeerReviewed application/pdf en http://utpedia.utp.edu.my/id/eprint/20508/1/ChoyShaoWei_18001859.pdf CHOY, SHAO WEI (2021) FIXEL BASED ANALYSIS: AGE AND GENDER-RELATED EFFECTS OF NORMAL HEALTHY AGING ON WHITE MATTER FIBRE. Masters thesis, Universiti Teknologi PETRONAS.
institution Universiti Teknologi Petronas
building UTP Resource Centre
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Petronas
content_source UTP Electronic and Digitized Intellectual Asset
url_provider http://utpedia.utp.edu.my/
language English
topic TK Electrical engineering. Electronics Nuclear engineering
spellingShingle TK Electrical engineering. Electronics Nuclear engineering
CHOY, SHAO WEI
FIXEL BASED ANALYSIS: AGE AND GENDER-RELATED EFFECTS OF NORMAL HEALTHY AGING ON WHITE MATTER FIBRE
description White matter fibre bundles change dynamically over the adulthood lifespan. These changes could be driven by the changes in axonal diameter, axonal density, and myelin content. In this study, the objective is to develop a pipeline to investigate the changes in fibre bundle characteristics related to a healthy ageing study by using the latest diffusion imaging technology. Limited studies had investigated alterations in fibre bundle characteristics with age, particularly in the range spanning early to late adulthood. We expanded the analysis by applying the fixel-based analysis framework using open-source pipelines with computing acceleration to examine the microscopic and macroscopic white matter changes throughout the adult lifespan. Additional processing steps were added to process low quality clinical data. By using the single shell (b=1000s/mm2) diffusion-weighted images and high-resolution T1 from a cohort of 293 healthy volunteers (89 males/204 females) ages 21 to 86 years old, we performed fixel based analysis to analyse age-related changes in microscopic fibre density and the macroscopic morphology, fibre cross-section. Whole-brain fixel based analysis was performed using the connectivity-based fixel enhancement technique to analyse the cross-sectional changes in fibre density and fibre cross-section measurements. The tract-level analysis was also performed on 11 major fibre tracts to evaluate the changes in white matter associated with age and gender.
format Thesis
author CHOY, SHAO WEI
author_facet CHOY, SHAO WEI
author_sort CHOY, SHAO WEI
title FIXEL BASED ANALYSIS: AGE AND GENDER-RELATED EFFECTS OF NORMAL HEALTHY AGING ON WHITE MATTER FIBRE
title_short FIXEL BASED ANALYSIS: AGE AND GENDER-RELATED EFFECTS OF NORMAL HEALTHY AGING ON WHITE MATTER FIBRE
title_full FIXEL BASED ANALYSIS: AGE AND GENDER-RELATED EFFECTS OF NORMAL HEALTHY AGING ON WHITE MATTER FIBRE
title_fullStr FIXEL BASED ANALYSIS: AGE AND GENDER-RELATED EFFECTS OF NORMAL HEALTHY AGING ON WHITE MATTER FIBRE
title_full_unstemmed FIXEL BASED ANALYSIS: AGE AND GENDER-RELATED EFFECTS OF NORMAL HEALTHY AGING ON WHITE MATTER FIBRE
title_sort fixel based analysis: age and gender-related effects of normal healthy aging on white matter fibre
publishDate 2021
url http://utpedia.utp.edu.my/id/eprint/20508/1/ChoyShaoWei_18001859.pdf
http://utpedia.utp.edu.my/id/eprint/20508/
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score 13.209306