Solubility of acyclovir in nontoxic and biodegradable ionic liquids: COSMO-RS prediction and experimental verification

• Main Authors: Lotfi, M., Moniruzzaman, M., Sivapragasam, M., Kandasamy, S., Abdul Mutalib, M.I., Alitheen, N.B., Goto, M.
• Format: Article
• Published: Elsevier B.V. 2017
• Online Access: http://scholars.utp.edu.my/id/eprint/19338/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85027977256&doi=10.1016%2fj.molliq.2017.08.020&partnerID=40&md5=1ba0e0f02e8b736a27830f0a0f6d9135

The pharmaceutical industry faces a challenge to find potential solvents for drug molecules that are sparingly soluble in water and conventional organic solvents. Recently, ionic liquids (ILs) have attracted great attention as pharmaceutical solvents owing to their unique physicochemical and biologi...