Outbreak detection model based on danger theory

• Main Authors: Mohamad Mohsin, Mohamad Farhan, Abu Bakar, Azuraliza, Hamdan, Abdul Razak
• Format: Article
• Published: Elsevier B.V. 2014
• Subjects: QA76 Computer software
• Online Access: http://repo.uum.edu.my/14124/; http://doi.org/10.1016/j.asoc.2014.08.030

In outbreak detection, one of the key issues is the need to deal with the weakness of early outbreak signals because this causes the detection model to have has less capability in terms of robustness when unseen outbreak patterns vary from those in the trained model. As a result, an imbalance between high detection rate and low false alarm rate occurs. To solve this problem, this study proposes a novel outbreak detection model based on danger theory; a bio-inspired method that replicates how the human body fights pathogens. We propose a signal formalization approach based on cumulative sum and a cumulative mature antigen contact value to suit the outbreak characteristic and danger theory. Two outbreak diseases, dengue and SARS, are subjected to a danger theory algorithm; namely the dendritic cell algorithm.To evaluate the model, four measurement metrics are applied: detection rate, specificity, false alarm rate, and accuracy. From the experiment, the proposed model outperforms the other detection approaches and shows a significant improvement for both diseases outbreak detection. The findings reveal that the robustness of the proposed immune model increases when dealing with inconsistent outbreak signals. The model is able to detect new unknown outbreak patterns and can discriminate between outbreak and non-outbreak cases with a consistent high detection rate, high sensitivity, and lower false alarm rate even without a training phase.