Inclusion Complexes of β-Cyclodextrin/Pioglitazone and β-Cyclodextrin-Ionic Liquid/Pioglitazone: Spectroscopic Methods Combined with Molecular Docking Studies

• Main Authors: Rahim, N.Y., Md Zuki, N.N., Jumbri, K., Mohamad, S., Abdul Manan, N.S., Sidek, N., Boon, Y.H., Ramachandran, M.R.
• Format: Conference or Workshop Item
• Published: Springer Science and Business Media B.V. 2021
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123292787&doi=10.1007%2f978-981-16-4513-6_12&partnerID=40&md5=9bd6713074d237de4fd0d25a45778084; http://eprints.utp.edu.my/29280/

The complexes of β-cyclodextrin/pioglitazone and β-cyclodextrin-ionic liquid/pioglitazone were prepared by kneading method. Characterization using FT-IR, thermogravimetric analysis and NMR had proven the formation of the complexes. From 1H NMR determination, pioglitazone is proven to form hydrogen bonding and inclusion complex with native β-cyclodextrin and β-cyclodextrin-ionic liquid. The molecular docking also reveals the same interaction involved for the formation of complexes β-cyclodextrin/pioglitazone and β-cyclodextrin-ionic liquid/pioglitazone. The binding energy obtained from molecular studies for the complex of β-cyclodextrin-ionic liquid/pioglitazone is higher than the binding energy of β-cyclodextrin/pioglitazone. © 2021, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.