Ionic-Liquid-Based Paclitaxel Preparation: A New Potential Formulation for Cancer Treatment

• Main Authors: Chowdhury, M.R., Moshikur, R.M., Wakabayashi, R., Tahara, Y., Kamiya, N., Moniruzzaman, M., Goto, M.
• Format: Article
• Published: American Chemical Society 2018
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047431364&doi=10.1021%2facs.molpharmaceut.8b00305&partnerID=40&md5=1686ee767f2f2e0a8b5ead1d550a6ca9; http://eprints.utp.edu.my/20856/

Paclitaxel (PTX) injection (i.e., Taxol) has been used as an effective chemotherapeutic treatment for various cancers. However, the current Taxol formulation contains Cremophor EL, which causes hypersensitivity reactions during intravenous administration and precipitation by aqueous dilution. This c...