Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: drug release, anti-microbial and cell viability studies
The composite hydrogels were produced using the solution casting method due to the non-toxic and biocompatible nature of chitosan (CS)/polyvinyl alcohol (PVA). The best composition was chosen and crosslinked with tetraethyl orthosilicate (TEOS), after which different amounts of graphene oxide (GO) w...
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my.utm.942822022-03-31T15:28:58Z http://eprints.utm.my/id/eprint/94282/ Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: drug release, anti-microbial and cell viability studies Khan, Muhammad Umar Aslam Yaqoob, Zahida Mohamed Ansari, Mohamed Nainar Abd. Razak, Saiful Izwan Ali Raza, Mohsin Sajjad, Amna Haider, Sajjad Busra, Fauzi Mh. Q Science (General) The composite hydrogels were produced using the solution casting method due to the non-toxic and biocompatible nature of chitosan (CS)/polyvinyl alcohol (PVA). The best composition was chosen and crosslinked with tetraethyl orthosilicate (TEOS), after which different amounts of graphene oxide (GO) were added to develop composite hydrogels. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM) and contact angle was used to analyze the hydrogels. The samples were also evaluated for swelling abilities in various mediums. The drug release profile was studied in phosphate-buffered saline (PBS) at a pH of 7.4. To predict the mechanism of drug release, the data were fitted into kinetic models. Finally, antibacterial activity and cell viability data were obtained. FTIR studies revealed the successful synthesis of CS/PVA hydrogels and GO/CS/PVA in hydrogel composite. SEM showed no phase separation of the polymers, whereas AFM showed a decrease in surface roughness with an increase in GO content. 100 µL of crosslinker was the critical concentration at which the sample displayed excellent swelling and preserved its structure. Both the crosslinked and composite hydrogel showed good swelling. The most acceptable mechanism of drug release is diffusion-controlled, and it obeys Fick’s law of diffusion for drug released. The best fitting of the zero-order, Hixson-Crowell and Higuchi models supported our assumption. The GO/CS/PVA hydrogel composite showed better antibacterial and cell viability behaviors. They can be better biomaterials in biomedical applications. MDPI 2021-09 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/94282/1/SaifulIzwan2021_ChitosanPolyVinylAlcoholGrapheneOxide.pdf Khan, Muhammad Umar Aslam and Yaqoob, Zahida and Mohamed Ansari, Mohamed Nainar and Abd. Razak, Saiful Izwan and Ali Raza, Mohsin and Sajjad, Amna and Haider, Sajjad and Busra, Fauzi Mh. (2021) Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: drug release, anti-microbial and cell viability studies. Polymers, 13 (18). pp. 1-19. ISSN 2073-4360 http://dx.doi.org/10.3390/polym13183124 DOI:10.3390/polym13183124 |
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Q Science (General) Khan, Muhammad Umar Aslam Yaqoob, Zahida Mohamed Ansari, Mohamed Nainar Abd. Razak, Saiful Izwan Ali Raza, Mohsin Sajjad, Amna Haider, Sajjad Busra, Fauzi Mh. Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: drug release, anti-microbial and cell viability studies |
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The composite hydrogels were produced using the solution casting method due to the non-toxic and biocompatible nature of chitosan (CS)/polyvinyl alcohol (PVA). The best composition was chosen and crosslinked with tetraethyl orthosilicate (TEOS), after which different amounts of graphene oxide (GO) were added to develop composite hydrogels. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM) and contact angle was used to analyze the hydrogels. The samples were also evaluated for swelling abilities in various mediums. The drug release profile was studied in phosphate-buffered saline (PBS) at a pH of 7.4. To predict the mechanism of drug release, the data were fitted into kinetic models. Finally, antibacterial activity and cell viability data were obtained. FTIR studies revealed the successful synthesis of CS/PVA hydrogels and GO/CS/PVA in hydrogel composite. SEM showed no phase separation of the polymers, whereas AFM showed a decrease in surface roughness with an increase in GO content. 100 µL of crosslinker was the critical concentration at which the sample displayed excellent swelling and preserved its structure. Both the crosslinked and composite hydrogel showed good swelling. The most acceptable mechanism of drug release is diffusion-controlled, and it obeys Fick’s law of diffusion for drug released. The best fitting of the zero-order, Hixson-Crowell and Higuchi models supported our assumption. The GO/CS/PVA hydrogel composite showed better antibacterial and cell viability behaviors. They can be better biomaterials in biomedical applications. |
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Article |
author |
Khan, Muhammad Umar Aslam Yaqoob, Zahida Mohamed Ansari, Mohamed Nainar Abd. Razak, Saiful Izwan Ali Raza, Mohsin Sajjad, Amna Haider, Sajjad Busra, Fauzi Mh. |
author_facet |
Khan, Muhammad Umar Aslam Yaqoob, Zahida Mohamed Ansari, Mohamed Nainar Abd. Razak, Saiful Izwan Ali Raza, Mohsin Sajjad, Amna Haider, Sajjad Busra, Fauzi Mh. |
author_sort |
Khan, Muhammad Umar Aslam |
title |
Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: drug release, anti-microbial and cell viability studies |
title_short |
Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: drug release, anti-microbial and cell viability studies |
title_full |
Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: drug release, anti-microbial and cell viability studies |
title_fullStr |
Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: drug release, anti-microbial and cell viability studies |
title_full_unstemmed |
Chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: drug release, anti-microbial and cell viability studies |
title_sort |
chitosan/poly vinyl alcohol/graphene oxide based ph-responsive composite hydrogel films: drug release, anti-microbial and cell viability studies |
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MDPI |
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2021 |
url |
http://eprints.utm.my/id/eprint/94282/1/SaifulIzwan2021_ChitosanPolyVinylAlcoholGrapheneOxide.pdf http://eprints.utm.my/id/eprint/94282/ http://dx.doi.org/10.3390/polym13183124 |
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1729703149990576128 |
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13.160551 |