NMF-based approach for missing values imputation of mass spectrometry metabolomics data

• Main Authors: Xu, Jingjing, Wang, Yuanshan, Xu, Xiangnan, Cheng, Kian Kai, Raftery, Daniel, Dong, Jiyang
• Format: Article
• Language: English
• Published: MDPI 2021
• Subjects: Q Science (General)
• Online Access: http://eprints.utm.my/id/eprint/94205/1/ChengKianKai2021_NMFBasedApproachforMissing.pdf; http://eprints.utm.my/id/eprint/94205/; http://dx.doi.org/10.3390/molecules26195787

In mass spectrometry (MS)-based metabolomics, missing values (NAs) may be due to different causes, including sample heterogeneity, ion suppression, spectral overlap, inappropriate data processing, and instrumental errors. Although a number of methodologies have been applied to handle NAs, NA imputat...