Novel functional antimicrobial and biocompatible arabinoxylan/guar gum hydrogel for skin wound dressing applications

It is a challenging task to develop active biomacromolecular wound dressing materials that are biocompatible and possesses antibacterial properties against the bacterial strains that cause severe skin disease. This work is focused on the preparation of a biocompatible and degradable hydrogel for wou...

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Main Authors: Khan, Muhammad Umar Aslam, Raza, Mohsin Ali, Abd. Razak, Saiful Izwan, Abdul Kadir, Mohammed Rafiq, Haider, Adnan, Shah, Saqlain A., Mohd. Yusof, Abdul Halim, Haider, Sajjad, Shakir, Imran, Aftab, Saira
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Published: John Wiley and Sons Ltd 2020
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Online Access:http://eprints.utm.my/id/eprint/92517/
http://dx.doi.org/10.1002/term.3115
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spelling my.utm.925172021-09-30T15:14:59Z http://eprints.utm.my/id/eprint/92517/ Novel functional antimicrobial and biocompatible arabinoxylan/guar gum hydrogel for skin wound dressing applications Khan, Muhammad Umar Aslam Raza, Mohsin Ali Abd. Razak, Saiful Izwan Abdul Kadir, Mohammed Rafiq Haider, Adnan Shah, Saqlain A. Mohd. Yusof, Abdul Halim Haider, Sajjad Shakir, Imran Aftab, Saira TP Chemical technology It is a challenging task to develop active biomacromolecular wound dressing materials that are biocompatible and possesses antibacterial properties against the bacterial strains that cause severe skin disease. This work is focused on the preparation of a biocompatible and degradable hydrogel for wound dressing application using arabinoxylan (ARX) and guar gum (GG) natural polymers. Fourier transform infrared spectroscopy (FT-IR) confirmed that both ARX and GG interacted well with each other, and their interactions further increased with the addition of crosslinker tetraethyl orthosilicate. Scanning electron microscope (SEM) micrographs showed uniform porous morphologies of the hydrogels. The porous morphologies and uniform interconnected pores are attributed to the increased crosslinking of the hydrogel. Elastic modulus, tensile strength, and fracture strain of the hydrogels significantly improved (from ATG-1 to ATG-4) with crosslinking. Degradability tests showed that hydrogels lost maximum weight in 7 days. All the samples showed variation in swelling with pH. Maximum swelling was observed at pH 7. The hydrogel samples showed good antibacterial activity against Pseudomonas aeruginosa (Gram-negative) and Staphylococcus aureus (Gram-positive) in PBS, good drug release profile (92% drug release), and nontoxic cellular behavior. The cells not only retained their cylindrical morphologies onto the hydrogel but were also performing their normal activities. It is, therefore, believed that as-developed hydrogel could be a potential material for wound dressing application. John Wiley and Sons Ltd 2020-10-01 Article PeerReviewed Khan, Muhammad Umar Aslam and Raza, Mohsin Ali and Abd. Razak, Saiful Izwan and Abdul Kadir, Mohammed Rafiq and Haider, Adnan and Shah, Saqlain A. and Mohd. Yusof, Abdul Halim and Haider, Sajjad and Shakir, Imran and Aftab, Saira (2020) Novel functional antimicrobial and biocompatible arabinoxylan/guar gum hydrogel for skin wound dressing applications. Journal of Tissue Engineering and Regenerative Medicine, 14 (10). pp. 1488-1501. ISSN 1932-6254 http://dx.doi.org/10.1002/term.3115 DOI:10.1002/term.3115
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Khan, Muhammad Umar Aslam
Raza, Mohsin Ali
Abd. Razak, Saiful Izwan
Abdul Kadir, Mohammed Rafiq
Haider, Adnan
Shah, Saqlain A.
Mohd. Yusof, Abdul Halim
Haider, Sajjad
Shakir, Imran
Aftab, Saira
Novel functional antimicrobial and biocompatible arabinoxylan/guar gum hydrogel for skin wound dressing applications
description It is a challenging task to develop active biomacromolecular wound dressing materials that are biocompatible and possesses antibacterial properties against the bacterial strains that cause severe skin disease. This work is focused on the preparation of a biocompatible and degradable hydrogel for wound dressing application using arabinoxylan (ARX) and guar gum (GG) natural polymers. Fourier transform infrared spectroscopy (FT-IR) confirmed that both ARX and GG interacted well with each other, and their interactions further increased with the addition of crosslinker tetraethyl orthosilicate. Scanning electron microscope (SEM) micrographs showed uniform porous morphologies of the hydrogels. The porous morphologies and uniform interconnected pores are attributed to the increased crosslinking of the hydrogel. Elastic modulus, tensile strength, and fracture strain of the hydrogels significantly improved (from ATG-1 to ATG-4) with crosslinking. Degradability tests showed that hydrogels lost maximum weight in 7 days. All the samples showed variation in swelling with pH. Maximum swelling was observed at pH 7. The hydrogel samples showed good antibacterial activity against Pseudomonas aeruginosa (Gram-negative) and Staphylococcus aureus (Gram-positive) in PBS, good drug release profile (92% drug release), and nontoxic cellular behavior. The cells not only retained their cylindrical morphologies onto the hydrogel but were also performing their normal activities. It is, therefore, believed that as-developed hydrogel could be a potential material for wound dressing application.
format Article
author Khan, Muhammad Umar Aslam
Raza, Mohsin Ali
Abd. Razak, Saiful Izwan
Abdul Kadir, Mohammed Rafiq
Haider, Adnan
Shah, Saqlain A.
Mohd. Yusof, Abdul Halim
Haider, Sajjad
Shakir, Imran
Aftab, Saira
author_facet Khan, Muhammad Umar Aslam
Raza, Mohsin Ali
Abd. Razak, Saiful Izwan
Abdul Kadir, Mohammed Rafiq
Haider, Adnan
Shah, Saqlain A.
Mohd. Yusof, Abdul Halim
Haider, Sajjad
Shakir, Imran
Aftab, Saira
author_sort Khan, Muhammad Umar Aslam
title Novel functional antimicrobial and biocompatible arabinoxylan/guar gum hydrogel for skin wound dressing applications
title_short Novel functional antimicrobial and biocompatible arabinoxylan/guar gum hydrogel for skin wound dressing applications
title_full Novel functional antimicrobial and biocompatible arabinoxylan/guar gum hydrogel for skin wound dressing applications
title_fullStr Novel functional antimicrobial and biocompatible arabinoxylan/guar gum hydrogel for skin wound dressing applications
title_full_unstemmed Novel functional antimicrobial and biocompatible arabinoxylan/guar gum hydrogel for skin wound dressing applications
title_sort novel functional antimicrobial and biocompatible arabinoxylan/guar gum hydrogel for skin wound dressing applications
publisher John Wiley and Sons Ltd
publishDate 2020
url http://eprints.utm.my/id/eprint/92517/
http://dx.doi.org/10.1002/term.3115
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score 13.209306