On the statistical analysis of the GS-NS0 cell proteome: Imputation, clustering and variability testing

• Main Authors: Ahmad, Norhaiza, Zhang, Jian, Brown, Phillip J., James, David C., Birch, John R., Racher, Andrew J., Smales, C. Mark
• Format: Article
• Published: Elsevier BV 2006
• Online Access: http://eprints.utm.my/id/eprint/9046/; http://dx.doi.org/10.1016/j.bbapap.2006.05.002

We have undertaken two-dimensional gel electrophoresis proteomic profiling on a series of cell lines with different recombinant antibody production rates. Due to the nature of gel-based experiments not all protein spots are detected across all samples in an experiment, and hence datasets are invaria...