C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma

• Main Authors: Nabizadeh, Jamileh A., Manthey, Helga D., Panagides, Nadya, Steyn, Frederik J., Lee, John D., Li, Xaria X., M. Akhir, Fazrena N., Chen, Weiyu, Boyle, Glen M., Taylor, Stephen M., Woodruff, Trent M., Rolfe, Barbara E.
• Format: Article
• Published: John Wiley and Sons Inc. 2019
• Subjects: TA Engineering (General). Civil engineering (General)
• Online Access: http://eprints.utm.my/id/eprint/89319/; http://dx.doi.org/10.1096/fj.201800980RR

The canonical complement component 5a (C5a) receptor (C5aR) 1 has well-described roles in tumorigenesis but the contribution of the second receptor, C5aR2, is unclear. The present study demonstrates that B16.F0 melanoma cells express mRNA for both C5aR1 and C5aR2 and signal through ERK and p38 MAPKs...