Electrospun polyurethane patch in combination with cedarwood and cobalt nitrate for cardiac applications

• Main Authors: Mani, Mohan Prasath, Jaganathan, Saravana Kumar, Prabhakaran, Praseetha, Nageswaran, Gomathi, Krishnasamy, Navaneetha Pandiyaraj
• Format: Article
• Published: John Wiley and Sons Inc. 2019
• Subjects: QH301 Biology
• Online Access: http://eprints.utm.my/id/eprint/89295/; http://dx.doi.org/10.1002/app.48226

The growth in nanotechnology led to the fabrication of scaffold at a low cost with high productivity and high surface area. The present research aims to fabricate a novel cardiac scaffold utilizing polyurethane (PU) added with cedarwood (CW) and cobalt nitrate (CoNO3) nanofibers. Morphological analysis showed that the mean fiber diameter of the PU nanofibers was reduced owing to the incorporation of CW and CoNO3. Infrared and thermal analysis revealed the interaction of PU with CW and CoNO3. Contact angle studies showed that the electrospun PU/CW displayed hydrophobic nature while PU/CW/CoNO3 showed hydrophilic behavior compared to the pristine PU. The tensile strength of PU nanofibers increased with CW and CoNO3 addition. Atomic force microscopy analysis depicted that the PU/CW was rougher while the PU/CW/CoNO3 as smoother surfaces than the pristine PU. According to the coagulation assay data, the blood compatibility of the electrospun composites was enhanced compared to the pristine PU. In addition, PU and its composite nanofibers exhibited non-toxic to human dermal fibroblast cells and improved cell proliferation rates compared to the control plates. To conclude, the improved physicochemical and biological response of the electrospun composites would be putative for cardiac tissue engineering. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48226.