Antitumor effect of fever range whole body hyperthermia with curcumin in breast cancer-induced mice
Breast cancer is a complex and heterogeneous disease and also one of the major cancer types among female worldwide. Fever range whole-body hyperthermia and curcumin as a single treatment have been tested against breast cancer and showed some promising anti-tumor effect. However, their combination as...
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my.utm.892542021-02-09T02:36:54Z http://eprints.utm.my/id/eprint/89254/ Antitumor effect of fever range whole body hyperthermia with curcumin in breast cancer-induced mice Saim, H. Salim, M. I. M. Jemon, K. Q Science (General) Breast cancer is a complex and heterogeneous disease and also one of the major cancer types among female worldwide. Fever range whole-body hyperthermia and curcumin as a single treatment have been tested against breast cancer and showed some promising anti-tumor effect. However, their combination as an effective anti-tumor treatment against breast cancer has never been explored. The effects of combined whole-body fever range hyperthermia and curcumin on tumor growth was examined in this study. Mice were inoculated with EMT6 cells subcutaneously and allocated to 4 treatment groups: (i) control (control), (ii) curcumin (50mg/kg bodyweight), (iii) twice fever range whole-body hyperthermia 39.0°C (± 0.5) for 15 minutes, (iv) a combination of curcumin (50mg/kg bodyweight) and twice fever range whole-body hyperthermia 39.0°C (± 0.5) for 15 minutes. Following treatment, mice body weight and tumor volume were measured. The greatest tumor growth inhibition exhibited in combination treatment (68.45%, p<0.05) and showed no general toxicity. As conclusion, the combination treatment can be a potential anti-tumor treatment of breast cancer. Blue Eyes Intelligence Engineering and Sciences Publication 2019-07 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/89254/1/HanimSaim2019_AntitumorEffectofFeverRangeWholeBody.pdf Saim, H. and Salim, M. I. M. and Jemon, K. (2019) Antitumor effect of fever range whole body hyperthermia with curcumin in breast cancer-induced mice. International Journal of Recent Technology and Engineering, 8 (2). pp. 297-301. ISSN 2277-3878 http://www.dx.doi.org/10.35940/ijrte.B1052.0782S219 DOI: 10.35940/ijrte.B1052.0782S219 |
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Breast cancer is a complex and heterogeneous disease and also one of the major cancer types among female worldwide. Fever range whole-body hyperthermia and curcumin as a single treatment have been tested against breast cancer and showed some promising anti-tumor effect. However, their combination as an effective anti-tumor treatment against breast cancer has never been explored. The effects of combined whole-body fever range hyperthermia and curcumin on tumor growth was examined in this study. Mice were inoculated with EMT6 cells subcutaneously and allocated to 4 treatment groups: (i) control (control), (ii) curcumin (50mg/kg bodyweight), (iii) twice fever range whole-body hyperthermia 39.0°C (± 0.5) for 15 minutes, (iv) a combination of curcumin (50mg/kg bodyweight) and twice fever range whole-body hyperthermia 39.0°C (± 0.5) for 15 minutes. Following treatment, mice body weight and tumor volume were measured. The greatest tumor growth inhibition exhibited in combination treatment (68.45%, p<0.05) and showed no general toxicity. As conclusion, the combination treatment can be a potential anti-tumor treatment of breast cancer. |
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Article |
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Saim, H. Salim, M. I. M. Jemon, K. |
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Saim, H. Salim, M. I. M. Jemon, K. |
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Saim, H. |
title |
Antitumor effect of fever range whole body hyperthermia with curcumin in breast cancer-induced mice |
title_short |
Antitumor effect of fever range whole body hyperthermia with curcumin in breast cancer-induced mice |
title_full |
Antitumor effect of fever range whole body hyperthermia with curcumin in breast cancer-induced mice |
title_fullStr |
Antitumor effect of fever range whole body hyperthermia with curcumin in breast cancer-induced mice |
title_full_unstemmed |
Antitumor effect of fever range whole body hyperthermia with curcumin in breast cancer-induced mice |
title_sort |
antitumor effect of fever range whole body hyperthermia with curcumin in breast cancer-induced mice |
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Blue Eyes Intelligence Engineering and Sciences Publication |
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2019 |
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http://eprints.utm.my/id/eprint/89254/1/HanimSaim2019_AntitumorEffectofFeverRangeWholeBody.pdf http://eprints.utm.my/id/eprint/89254/ http://www.dx.doi.org/10.35940/ijrte.B1052.0782S219 |
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