In vitro blood compatibility and bone mineralization aspects of polymeric scaffold laden with essential oil and metallic particles for bone tissue engineering
Bone tissue engineering scaffolds necessities appropriate physicochemical and mechanical properties to support its renewal. Electrospun scaffolds have been used unequivocally in bone tissue restoration. The main intention of this research is to develop electrospun polyurethane (PU) scaffold decorate...
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my.utm.884712020-12-15T00:06:46Z http://eprints.utm.my/id/eprint/88471/ In vitro blood compatibility and bone mineralization aspects of polymeric scaffold laden with essential oil and metallic particles for bone tissue engineering Zhang, Zhizhong Zheng, Yu Zhang, Lipeng Mani, Mohan Prasath Jaganathan, Saravana Kumar Q Science (General) Bone tissue engineering scaffolds necessities appropriate physicochemical and mechanical properties to support its renewal. Electrospun scaffolds have been used unequivocally in bone tissue restoration. The main intention of this research is to develop electrospun polyurethane (PU) scaffold decorated with metallic particles and essential oil with advanced properties to make them as a putative candidate. The nanocomposite scaffold exhibited appropriate wettability and suitable fiber diameter compared to the polyurethane scaffold. Interaction of the added constituents with the polyurethane was corroborated through hydrogen bonding formation. Tensile strength of the composites was enhanced compared to the polyurethane scaffold. Thermal analysis depicted the lower weight loss of the composite scaffold than the pristine PU. Blood coagulation was significantly delayed and also the composite surface rendered safe interaction with red blood cells. In vitro toxicity testing using fibroblast cells portrayed the nontoxic behavior of the fabricated material. The above-said advanced properties of the composite scaffold can be warranted for bone tissue engineering application. Taylor and Francis Inc. 2019 Article PeerReviewed Zhang, Zhizhong and Zheng, Yu and Zhang, Lipeng and Mani, Mohan Prasath and Jaganathan, Saravana Kumar (2019) In vitro blood compatibility and bone mineralization aspects of polymeric scaffold laden with essential oil and metallic particles for bone tissue engineering. International Journal of Polymer Analysis and Characterization, 24 (6). pp. 504-516. ISSN 1023-666X http://dx.doi.org/10.1080/1023666X.2019.1611029 |
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Q Science (General) Zhang, Zhizhong Zheng, Yu Zhang, Lipeng Mani, Mohan Prasath Jaganathan, Saravana Kumar In vitro blood compatibility and bone mineralization aspects of polymeric scaffold laden with essential oil and metallic particles for bone tissue engineering |
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Bone tissue engineering scaffolds necessities appropriate physicochemical and mechanical properties to support its renewal. Electrospun scaffolds have been used unequivocally in bone tissue restoration. The main intention of this research is to develop electrospun polyurethane (PU) scaffold decorated with metallic particles and essential oil with advanced properties to make them as a putative candidate. The nanocomposite scaffold exhibited appropriate wettability and suitable fiber diameter compared to the polyurethane scaffold. Interaction of the added constituents with the polyurethane was corroborated through hydrogen bonding formation. Tensile strength of the composites was enhanced compared to the polyurethane scaffold. Thermal analysis depicted the lower weight loss of the composite scaffold than the pristine PU. Blood coagulation was significantly delayed and also the composite surface rendered safe interaction with red blood cells. In vitro toxicity testing using fibroblast cells portrayed the nontoxic behavior of the fabricated material. The above-said advanced properties of the composite scaffold can be warranted for bone tissue engineering application. |
format |
Article |
author |
Zhang, Zhizhong Zheng, Yu Zhang, Lipeng Mani, Mohan Prasath Jaganathan, Saravana Kumar |
author_facet |
Zhang, Zhizhong Zheng, Yu Zhang, Lipeng Mani, Mohan Prasath Jaganathan, Saravana Kumar |
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Zhang, Zhizhong |
title |
In vitro blood compatibility and bone mineralization aspects of polymeric scaffold laden with essential oil and metallic particles for bone tissue engineering |
title_short |
In vitro blood compatibility and bone mineralization aspects of polymeric scaffold laden with essential oil and metallic particles for bone tissue engineering |
title_full |
In vitro blood compatibility and bone mineralization aspects of polymeric scaffold laden with essential oil and metallic particles for bone tissue engineering |
title_fullStr |
In vitro blood compatibility and bone mineralization aspects of polymeric scaffold laden with essential oil and metallic particles for bone tissue engineering |
title_full_unstemmed |
In vitro blood compatibility and bone mineralization aspects of polymeric scaffold laden with essential oil and metallic particles for bone tissue engineering |
title_sort |
in vitro blood compatibility and bone mineralization aspects of polymeric scaffold laden with essential oil and metallic particles for bone tissue engineering |
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Taylor and Francis Inc. |
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2019 |
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http://eprints.utm.my/id/eprint/88471/ http://dx.doi.org/10.1080/1023666X.2019.1611029 |
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13.159267 |