Pilot scale extraction of orthosiphon stamineus raw material as rosmarinic acid extract
A scale-up protocol for rosmarinic acid extraction from Orthosiphon stamineus was developed using the concept of constant power dissipation for a similar kinetic profile. Rosmarinic acid is the bioactive compound in the herb and therefore, large scale extraction for that compound is important for co...
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Online Access: | http://eprints.utm.my/id/eprint/88096/1/LeeSuanChua2019_PilotScaleExtractionofOrthosiphonstamineus.pdf http://eprints.utm.my/id/eprint/88096/ https://doi.org/10.3390/agriengineering1010007 |
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my.utm.880962020-12-14T22:59:09Z http://eprints.utm.my/id/eprint/88096/ Pilot scale extraction of orthosiphon stamineus raw material as rosmarinic acid extract Cher, Haan Lau Lee, Suan Chua TP Chemical technology A scale-up protocol for rosmarinic acid extraction from Orthosiphon stamineus was developed using the concept of constant power dissipation for a similar kinetic profile. Rosmarinic acid is the bioactive compound in the herb and therefore, large scale extraction for that compound is important for commercial application. The first-order kinetic equation which was established in the preparative scale extraction was used to describe the extraction of rosmarinic acid from the herb. The agitation speed of the pilot large-scale extractor (451 rpm) was determined based on the constant power dissipation to meet the minimal required speed, namely just-suspended speed (Njs), 450.84 ± 0.88 rpm. The experimental data was fitted well to the proposed kinetic equation with a high correlation coefficient, R2 0.88, and a low root mean square error, RMSE 3.85. This indicates the good performance of the scale-up approach based on the dynamic criterion. Therefore, the use of constant power dissipation to obtain a similar kinetic profile could be applied for phytochemical extraction from herbal plants. MDPI AG 2019 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/88096/1/LeeSuanChua2019_PilotScaleExtractionofOrthosiphonstamineus.pdf Cher, Haan Lau and Lee, Suan Chua (2019) Pilot scale extraction of orthosiphon stamineus raw material as rosmarinic acid extract. Agri Engineering, 1 (1). pp. 94-99. ISSN 2624-7402 https://doi.org/10.3390/agriengineering1010007 DOI:10.3390/agriengineering1010007 |
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TP Chemical technology Cher, Haan Lau Lee, Suan Chua Pilot scale extraction of orthosiphon stamineus raw material as rosmarinic acid extract |
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A scale-up protocol for rosmarinic acid extraction from Orthosiphon stamineus was developed using the concept of constant power dissipation for a similar kinetic profile. Rosmarinic acid is the bioactive compound in the herb and therefore, large scale extraction for that compound is important for commercial application. The first-order kinetic equation which was established in the preparative scale extraction was used to describe the extraction of rosmarinic acid from the herb. The agitation speed of the pilot large-scale extractor (451 rpm) was determined based on the constant power dissipation to meet the minimal required speed, namely just-suspended speed (Njs), 450.84 ± 0.88 rpm. The experimental data was fitted well to the proposed kinetic equation with a high correlation coefficient, R2 0.88, and a low root mean square error, RMSE 3.85. This indicates the good performance of the scale-up approach based on the dynamic criterion. Therefore, the use of constant power dissipation to obtain a similar kinetic profile could be applied for phytochemical extraction from herbal plants. |
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Cher, Haan Lau Lee, Suan Chua |
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Cher, Haan Lau Lee, Suan Chua |
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Cher, Haan Lau |
title |
Pilot scale extraction of orthosiphon stamineus raw material as rosmarinic acid extract |
title_short |
Pilot scale extraction of orthosiphon stamineus raw material as rosmarinic acid extract |
title_full |
Pilot scale extraction of orthosiphon stamineus raw material as rosmarinic acid extract |
title_fullStr |
Pilot scale extraction of orthosiphon stamineus raw material as rosmarinic acid extract |
title_full_unstemmed |
Pilot scale extraction of orthosiphon stamineus raw material as rosmarinic acid extract |
title_sort |
pilot scale extraction of orthosiphon stamineus raw material as rosmarinic acid extract |
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MDPI AG |
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2019 |
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http://eprints.utm.my/id/eprint/88096/1/LeeSuanChua2019_PilotScaleExtractionofOrthosiphonstamineus.pdf http://eprints.utm.my/id/eprint/88096/ https://doi.org/10.3390/agriengineering1010007 |
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