Electrodeposition of ginseng/polyaniline encapsulated poly(lactic-co-glycolic acid) microcapsule coating on stainless steel 316L at different deposition parameters
Electrodeposition is commonly used to deposit ceramic or metal coating on metallic implants. Its utilization in depositing polymer microcapsule coating is currently being explored. However, there is no encapsulation of drug within polymer microcapsules that will enhance its chemical and biological p...
Saved in:
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Pharmaceutical Society of Japan
2019
|
Subjects: | |
Online Access: | http://eprints.utm.my/id/eprint/87733/1/SitiKhadijahLukman2019_ElectrodepositionofGinsengPolyanilineEncapsulatedPoly.pdf http://eprints.utm.my/id/eprint/87733/ http://dx.doi.org/10.1248/cpb.c18-00847 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.utm.87733 |
---|---|
record_format |
eprints |
spelling |
my.utm.877332020-11-30T13:15:11Z http://eprints.utm.my/id/eprint/87733/ Electrodeposition of ginseng/polyaniline encapsulated poly(lactic-co-glycolic acid) microcapsule coating on stainless steel 316L at different deposition parameters Lukman, Siti Khadijah Al-Ashwal, Rania Hussein Sultana, Naznin Saidin, Syafiqah TA Engineering (General). Civil engineering (General) TP Chemical technology Electrodeposition is commonly used to deposit ceramic or metal coating on metallic implants. Its utilization in depositing polymer microcapsule coating is currently being explored. However, there is no encapsulation of drug within polymer microcapsules that will enhance its chemical and biological properties. Therefore, in this study, ginseng which is known for its multiple therapeutic effects was encapsulated inside biodegradable poly(lactic-co-glycolic acid) (PLGA) microcapsules to be coated on pre-treated medical grade stainless steel 316L (SS316L) using an electrodeposition technique. Polyaniline (PANI) was incorporated within the microcapsules to drive the formation of microcapsule coating. The electrodeposition was performed at different current densities (1–3mA) and different deposition times (20–60s). The chemical composition, morphology and wettability of the microcapsule coatings were characterized through attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM) and contact angle analyses. The changes of electrolyte colors, before and after the electrodeposition were also observed. The addition of PANI has formed low wettability and uniform microcapsule coatings at 2mA current density and 40s deposition time. Reduction in the current density or deposition time caused less attachment of microcapsule coatings with high wettability records. While prolonging either one parameter has led to debris formation and melted microcapsules with non-uniform wettability measurements. The color of electrolytes was also changed from milky white to dark yellow when the current density and deposition time increased. The application of tolerable current density and deposition time is crucial to obtain a uniform microcapsule coating, projecting a controlled release of encapsulated drug. Pharmaceutical Society of Japan 2019 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/87733/1/SitiKhadijahLukman2019_ElectrodepositionofGinsengPolyanilineEncapsulatedPoly.pdf Lukman, Siti Khadijah and Al-Ashwal, Rania Hussein and Sultana, Naznin and Saidin, Syafiqah (2019) Electrodeposition of ginseng/polyaniline encapsulated poly(lactic-co-glycolic acid) microcapsule coating on stainless steel 316L at different deposition parameters. Chemical and Pharmaceutical Bulletin, 67 (5). pp. 445-451. ISSN 0009-2363 http://dx.doi.org/10.1248/cpb.c18-00847 DOI:10.1248/cpb.c18-00847 |
institution |
Universiti Teknologi Malaysia |
building |
UTM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Teknologi Malaysia |
content_source |
UTM Institutional Repository |
url_provider |
http://eprints.utm.my/ |
language |
English |
topic |
TA Engineering (General). Civil engineering (General) TP Chemical technology |
spellingShingle |
TA Engineering (General). Civil engineering (General) TP Chemical technology Lukman, Siti Khadijah Al-Ashwal, Rania Hussein Sultana, Naznin Saidin, Syafiqah Electrodeposition of ginseng/polyaniline encapsulated poly(lactic-co-glycolic acid) microcapsule coating on stainless steel 316L at different deposition parameters |
description |
Electrodeposition is commonly used to deposit ceramic or metal coating on metallic implants. Its utilization in depositing polymer microcapsule coating is currently being explored. However, there is no encapsulation of drug within polymer microcapsules that will enhance its chemical and biological properties. Therefore, in this study, ginseng which is known for its multiple therapeutic effects was encapsulated inside biodegradable poly(lactic-co-glycolic acid) (PLGA) microcapsules to be coated on pre-treated medical grade stainless steel 316L (SS316L) using an electrodeposition technique. Polyaniline (PANI) was incorporated within the microcapsules to drive the formation of microcapsule coating. The electrodeposition was performed at different current densities (1–3mA) and different deposition times (20–60s). The chemical composition, morphology and wettability of the microcapsule coatings were characterized through attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM) and contact angle analyses. The changes of electrolyte colors, before and after the electrodeposition were also observed. The addition of PANI has formed low wettability and uniform microcapsule coatings at 2mA current density and 40s deposition time. Reduction in the current density or deposition time caused less attachment of microcapsule coatings with high wettability records. While prolonging either one parameter has led to debris formation and melted microcapsules with non-uniform wettability measurements. The color of electrolytes was also changed from milky white to dark yellow when the current density and deposition time increased. The application of tolerable current density and deposition time is crucial to obtain a uniform microcapsule coating, projecting a controlled release of encapsulated drug. |
format |
Article |
author |
Lukman, Siti Khadijah Al-Ashwal, Rania Hussein Sultana, Naznin Saidin, Syafiqah |
author_facet |
Lukman, Siti Khadijah Al-Ashwal, Rania Hussein Sultana, Naznin Saidin, Syafiqah |
author_sort |
Lukman, Siti Khadijah |
title |
Electrodeposition of ginseng/polyaniline encapsulated poly(lactic-co-glycolic acid) microcapsule coating on stainless steel 316L at different deposition parameters |
title_short |
Electrodeposition of ginseng/polyaniline encapsulated poly(lactic-co-glycolic acid) microcapsule coating on stainless steel 316L at different deposition parameters |
title_full |
Electrodeposition of ginseng/polyaniline encapsulated poly(lactic-co-glycolic acid) microcapsule coating on stainless steel 316L at different deposition parameters |
title_fullStr |
Electrodeposition of ginseng/polyaniline encapsulated poly(lactic-co-glycolic acid) microcapsule coating on stainless steel 316L at different deposition parameters |
title_full_unstemmed |
Electrodeposition of ginseng/polyaniline encapsulated poly(lactic-co-glycolic acid) microcapsule coating on stainless steel 316L at different deposition parameters |
title_sort |
electrodeposition of ginseng/polyaniline encapsulated poly(lactic-co-glycolic acid) microcapsule coating on stainless steel 316l at different deposition parameters |
publisher |
Pharmaceutical Society of Japan |
publishDate |
2019 |
url |
http://eprints.utm.my/id/eprint/87733/1/SitiKhadijahLukman2019_ElectrodepositionofGinsengPolyanilineEncapsulatedPoly.pdf http://eprints.utm.my/id/eprint/87733/ http://dx.doi.org/10.1248/cpb.c18-00847 |
_version_ |
1685578981035737088 |
score |
13.160551 |