Bioassay-guided different extraction techniques of carica papaya (Linn.) leaves on in vitro wound-healing activities

• Main Authors: Soib, Husnul Hanani, Ismail, H. F., Husin, F., Abu Bakar, M. H., Yaakob, Harisun, Sarmidi, Mohamad Roji
• Format: Article
• Language: English
• Published: MDPI AG 2020
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/86450/1/HusnulHanani2020_BioassayGuidedDifferentExtractionTechniques.pdf; http://eprints.utm.my/id/eprint/86450/; https://dx.doi.org/10.3390/molecules25030517

Herbal plants are traditionally utilized to treat various illnesses. They contain phytochemicals that can be extracted using conventional methods such as maceration, soxhlet, and boiling, as well as non-conventional methods including ultrasonic, microwave, and others. Carica papaya leaves have been used for the treatment of dengue, fungal, and bacterial infections as well as an ingredient in anti-aging products. Phytochemicals analysis detected the presence of kaempferol, myricetin, carpaine, pseudocarpaine, dehydrocarpaine I and II, ferulic acid, caffeic acid, chlorogenic acid, beta-carotene, lycopene, and anthraquinones glycoside. Conventional preparation by boiling and simple maceration is practical, simple, and safe; however, only polar phytochemicals are extracted.