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Anticancer potentials of zinc oxide nanoparticles against liver and breast cancer cell lines

The aim of the present study was to evaluate the in vitro cytotoxic effects of zinc oxide nanoparticles (ZnONPs) with particle size of 40 and 50 nm against human hepatocellular carcinoma and human breast cancer cell lines. The effects of nanoparticles were analyzed after 24 hours of incubation using...

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Main Authors: Elsayed, E. A., Moussa, S. A., El-Enshasy, H. A., Wadaan, M. A.
Format: Article
Published: Scientific Publishers 2020
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/86447/
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spelling my.utm.864472020-09-09T07:20:40Z http://eprints.utm.my/id/eprint/86447/ Anticancer potentials of zinc oxide nanoparticles against liver and breast cancer cell lines Elsayed, E. A. Moussa, S. A. El-Enshasy, H. A. Wadaan, M. A. TP Chemical technology The aim of the present study was to evaluate the in vitro cytotoxic effects of zinc oxide nanoparticles (ZnONPs) with particle size of 40 and 50 nm against human hepatocellular carcinoma and human breast cancer cell lines. The effects of nanoparticles were analyzed after 24 hours of incubation using standard MTT assay. Incubation of ZnONPs with different cells produced a dose-dependent inhibition of cell growth. The IC50 values of ZnONPs for both prepared samples (40 and 50 nm) were comparable. It has been noticed that MCF-7 and MDA cells were more affected by the prepared 50 nm than the 40 nm ZnONPs. On the other hand, HepG2 cells showed inverse relation in terms of their response to the size of the prepared NPs. Scientific Publishers 2020 Article PeerReviewed Elsayed, E. A. and Moussa, S. A. and El-Enshasy, H. A. and Wadaan, M. A. (2020) Anticancer potentials of zinc oxide nanoparticles against liver and breast cancer cell lines. Journal of Scientific and Industrial Research, 79 (1). pp. 56-59. ISSN 0022-4456
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TP Chemical technology
spellingShingle TP Chemical technology
Elsayed, E. A.
Moussa, S. A.
El-Enshasy, H. A.
Wadaan, M. A.
Anticancer potentials of zinc oxide nanoparticles against liver and breast cancer cell lines
description The aim of the present study was to evaluate the in vitro cytotoxic effects of zinc oxide nanoparticles (ZnONPs) with particle size of 40 and 50 nm against human hepatocellular carcinoma and human breast cancer cell lines. The effects of nanoparticles were analyzed after 24 hours of incubation using standard MTT assay. Incubation of ZnONPs with different cells produced a dose-dependent inhibition of cell growth. The IC50 values of ZnONPs for both prepared samples (40 and 50 nm) were comparable. It has been noticed that MCF-7 and MDA cells were more affected by the prepared 50 nm than the 40 nm ZnONPs. On the other hand, HepG2 cells showed inverse relation in terms of their response to the size of the prepared NPs.
format Article
author Elsayed, E. A.
Moussa, S. A.
El-Enshasy, H. A.
Wadaan, M. A.
author_facet Elsayed, E. A.
Moussa, S. A.
El-Enshasy, H. A.
Wadaan, M. A.
author_sort Elsayed, E. A.
title Anticancer potentials of zinc oxide nanoparticles against liver and breast cancer cell lines
title_short Anticancer potentials of zinc oxide nanoparticles against liver and breast cancer cell lines
title_full Anticancer potentials of zinc oxide nanoparticles against liver and breast cancer cell lines
title_fullStr Anticancer potentials of zinc oxide nanoparticles against liver and breast cancer cell lines
title_full_unstemmed Anticancer potentials of zinc oxide nanoparticles against liver and breast cancer cell lines
title_sort anticancer potentials of zinc oxide nanoparticles against liver and breast cancer cell lines
publisher Scientific Publishers
publishDate 2020
url http://eprints.utm.my/id/eprint/86447/
_version_ 1677781179233730560
score 13.160551

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