Structure prediction on large protein using the combination of knowledge based and physics based approaches method validation on cholesterol esterase

• Main Authors: Ahmad Khairuddin, N. B., Wahab, H. A., Samian, M. R., Najimudin, N.
• Format: Article
• Language: English
• Published: Faculty of Chemical Engineering & Natural Resources 2008
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/8576/1/NBAhmadKhairudin2008_StructurePredictionofLargeProteinUsing.pdf; http://eprints.utm.my/id/eprint/8576/; http://www.fkkksa.utm.my/jcnre/

The objective of this study was to predict the structure of a large protein using a combined approach of knowledge-based comparative modeling and physics-based Molecular Dynamics (MD) simulation applied to the enzyme cholesterol esterase. The core region of the enzyme was modelled using information...