Wavelength and dose-dependent effects of photobiomodulation therapy on wound healing in rat model
Photobiomodulation therapy (PBMT) is the use of near infrared light to stimulate tissue repair in the healing process. The aim of this study was to evaluate the wavelength- and dose-dependent effects of PBMT on wound healing. Thirty-six Sprague Dawley rats with four circular full thickness 6 mm diam...
Saved in:
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Published: |
Institute of Physics Publishing
2018
|
Subjects: | |
Online Access: | http://eprints.utm.my/id/eprint/85668/ http://dx.doi.org/10.1088/1555-6611/aad84b |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.utm.85668 |
---|---|
record_format |
eprints |
spelling |
my.utm.856682020-07-20T01:24:12Z http://eprints.utm.my/id/eprint/85668/ Wavelength and dose-dependent effects of photobiomodulation therapy on wound healing in rat model Abdul Munap, Daing Hanum Farhana Bakhtiar, Hazri Bidin, Noriah Krishnan, Ganesan Nabila, Azilah Johari, Noor Hidayu Zakaria, Nurlaily Abu Bakar, M. Aizat Pik, Suan Lau QC Physics Photobiomodulation therapy (PBMT) is the use of near infrared light to stimulate tissue repair in the healing process. The aim of this study was to evaluate the wavelength- and dose-dependent effects of PBMT on wound healing. Thirty-six Sprague Dawley rats with four circular full thickness 6 mm diameter cutaneous wounds each were distributed into experimental part 1 for optimization of wavelengths on wound treatment and experimental part 2 for dose-dependent studies. In part 1, various near infrared laser wavelengths (808, 880 and 1064 nm) were used as PBMT light source to optimize the wound treatment under the same fluence of 5 J cm-2. Furthermore, the optimal wavelength was selected as treatment source in part 2 with various power densities in the range of 20-100 mW cm-2. All wounds were treated immediately except for the control group and the experiment was conducted for nine consecutive days. The result in part 1 showed that 808 nm was the optimal wavelength to give the highest wound closure percentage at 94.08% ± 6.5%, meanwhile power density of 40-60 mW cm-2 better accelerated the healing rate than other groups in part 2. Therefore, PBMT using 808 nm at the range of 40-60 mW cm-2 has beneficial effects on the wound healing process. Institute of Physics Publishing 2018-11 Article PeerReviewed Abdul Munap, Daing Hanum Farhana and Bakhtiar, Hazri and Bidin, Noriah and Krishnan, Ganesan and Nabila, Azilah and Johari, Noor Hidayu and Zakaria, Nurlaily and Abu Bakar, M. Aizat and Pik, Suan Lau (2018) Wavelength and dose-dependent effects of photobiomodulation therapy on wound healing in rat model. Laser Physics, 28 (11). ISSN 1054-660X http://dx.doi.org/10.1088/1555-6611/aad84b DOI:10.1088/1555-6611/aad84b |
institution |
Universiti Teknologi Malaysia |
building |
UTM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Teknologi Malaysia |
content_source |
UTM Institutional Repository |
url_provider |
http://eprints.utm.my/ |
topic |
QC Physics |
spellingShingle |
QC Physics Abdul Munap, Daing Hanum Farhana Bakhtiar, Hazri Bidin, Noriah Krishnan, Ganesan Nabila, Azilah Johari, Noor Hidayu Zakaria, Nurlaily Abu Bakar, M. Aizat Pik, Suan Lau Wavelength and dose-dependent effects of photobiomodulation therapy on wound healing in rat model |
description |
Photobiomodulation therapy (PBMT) is the use of near infrared light to stimulate tissue repair in the healing process. The aim of this study was to evaluate the wavelength- and dose-dependent effects of PBMT on wound healing. Thirty-six Sprague Dawley rats with four circular full thickness 6 mm diameter cutaneous wounds each were distributed into experimental part 1 for optimization of wavelengths on wound treatment and experimental part 2 for dose-dependent studies. In part 1, various near infrared laser wavelengths (808, 880 and 1064 nm) were used as PBMT light source to optimize the wound treatment under the same fluence of 5 J cm-2. Furthermore, the optimal wavelength was selected as treatment source in part 2 with various power densities in the range of 20-100 mW cm-2. All wounds were treated immediately except for the control group and the experiment was conducted for nine consecutive days. The result in part 1 showed that 808 nm was the optimal wavelength to give the highest wound closure percentage at 94.08% ± 6.5%, meanwhile power density of 40-60 mW cm-2 better accelerated the healing rate than other groups in part 2. Therefore, PBMT using 808 nm at the range of 40-60 mW cm-2 has beneficial effects on the wound healing process. |
format |
Article |
author |
Abdul Munap, Daing Hanum Farhana Bakhtiar, Hazri Bidin, Noriah Krishnan, Ganesan Nabila, Azilah Johari, Noor Hidayu Zakaria, Nurlaily Abu Bakar, M. Aizat Pik, Suan Lau |
author_facet |
Abdul Munap, Daing Hanum Farhana Bakhtiar, Hazri Bidin, Noriah Krishnan, Ganesan Nabila, Azilah Johari, Noor Hidayu Zakaria, Nurlaily Abu Bakar, M. Aizat Pik, Suan Lau |
author_sort |
Abdul Munap, Daing Hanum Farhana |
title |
Wavelength and dose-dependent effects of photobiomodulation therapy on wound healing in rat model |
title_short |
Wavelength and dose-dependent effects of photobiomodulation therapy on wound healing in rat model |
title_full |
Wavelength and dose-dependent effects of photobiomodulation therapy on wound healing in rat model |
title_fullStr |
Wavelength and dose-dependent effects of photobiomodulation therapy on wound healing in rat model |
title_full_unstemmed |
Wavelength and dose-dependent effects of photobiomodulation therapy on wound healing in rat model |
title_sort |
wavelength and dose-dependent effects of photobiomodulation therapy on wound healing in rat model |
publisher |
Institute of Physics Publishing |
publishDate |
2018 |
url |
http://eprints.utm.my/id/eprint/85668/ http://dx.doi.org/10.1088/1555-6611/aad84b |
_version_ |
1674066190513733632 |
score |
13.188404 |