Polysulfone hemodialysis membrane incorporated with Fe2O3 for enhanced removal of middle molecular weight uremic toxin
Removing middle molecular weight uremic toxin remains as one of the most challenging tasks in hemodialysis. Hence, in this study a high performance polysulfone (PSf) hemodialysis membrane was developed by incorporating iron oxide (Fe2O3) nanoparticles. The PSf/Fe2O3 hemodialysis membrane and pristin...
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my.utm.855602020-06-30T08:50:32Z http://eprints.utm.my/id/eprint/85560/ Polysulfone hemodialysis membrane incorporated with Fe2O3 for enhanced removal of middle molecular weight uremic toxin Said, Noresah Zainol Abidin, Muhammad Nidzhom Hasbullah, Hasrinah Ismail, Ahmad Fauzi Pei, Sean Goh Othman, Mohd. Hafiz Dzarfan Abdullah, Mohd. Sohaimi Be, Cheer Ng Abdul Kadir, Siti Hamimah Sheikh Kamal, Fatmawati TP Chemical technology Removing middle molecular weight uremic toxin remains as one of the most challenging tasks in hemodialysis. Hence, in this study a high performance polysulfone (PSf) hemodialysis membrane was developed by incorporating iron oxide (Fe2O3) nanoparticles. The PSf/Fe2O3 hemodialysis membrane and pristine PSf membrane were prepared via dry-wet spinning process. The membranes were characterized by scanning electron microscopy, water contact angle, average pore size, and porosity measurements. The biocompatibility profiles of the membranes were also evaluated in terms of protein adsorption and blood coagulation time. Next, the performance of the membranes was determined by measuring pure water permeability (PWP), bovine serum albumin rejection, and removal of various solutes such as urea and lysozyme. The incorporation of Fe2O3 resulted in significant increment of the PWP from 40.74 L/m2/h/bar to 58.6 L/m2/h/bar, mainly due to the improved water transport properties of the membrane. Moreover, the percent removal of urea and lysozyme was reported to be 75.1% and 35.6%, respectively. PSf/Fe2O3 hemodialysis membrane is proven to have a bright prospect for enhanced blood purification process. Penerbit UTM Press 2020 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/85560/1/AhmadFauziIsmail2020_PolysulfoneHemodialysisMembraneIncorporated.pdf Said, Noresah and Zainol Abidin, Muhammad Nidzhom and Hasbullah, Hasrinah and Ismail, Ahmad Fauzi and Pei, Sean Goh and Othman, Mohd. Hafiz Dzarfan and Abdullah, Mohd. Sohaimi and Be, Cheer Ng and Abdul Kadir, Siti Hamimah Sheikh and Kamal, Fatmawati (2020) Polysulfone hemodialysis membrane incorporated with Fe2O3 for enhanced removal of middle molecular weight uremic toxin. Malaysian Journal of Fundamental and Applied Sciences, 16 (1). pp. 1-5. ISSN 2289-5981 https://mjfas.utm.my/index.php/mjfas/article/view/1464 |
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TP Chemical technology Said, Noresah Zainol Abidin, Muhammad Nidzhom Hasbullah, Hasrinah Ismail, Ahmad Fauzi Pei, Sean Goh Othman, Mohd. Hafiz Dzarfan Abdullah, Mohd. Sohaimi Be, Cheer Ng Abdul Kadir, Siti Hamimah Sheikh Kamal, Fatmawati Polysulfone hemodialysis membrane incorporated with Fe2O3 for enhanced removal of middle molecular weight uremic toxin |
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Removing middle molecular weight uremic toxin remains as one of the most challenging tasks in hemodialysis. Hence, in this study a high performance polysulfone (PSf) hemodialysis membrane was developed by incorporating iron oxide (Fe2O3) nanoparticles. The PSf/Fe2O3 hemodialysis membrane and pristine PSf membrane were prepared via dry-wet spinning process. The membranes were characterized by scanning electron microscopy, water contact angle, average pore size, and porosity measurements. The biocompatibility profiles of the membranes were also evaluated in terms of protein adsorption and blood coagulation time. Next, the performance of the membranes was determined by measuring pure water permeability (PWP), bovine serum albumin rejection, and removal of various solutes such as urea and lysozyme. The incorporation of Fe2O3 resulted in significant increment of the PWP from 40.74 L/m2/h/bar to 58.6 L/m2/h/bar, mainly due to the improved water transport properties of the membrane. Moreover, the percent removal of urea and lysozyme was reported to be 75.1% and 35.6%, respectively. PSf/Fe2O3 hemodialysis membrane is proven to have a bright prospect for enhanced blood purification process. |
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Article |
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Said, Noresah Zainol Abidin, Muhammad Nidzhom Hasbullah, Hasrinah Ismail, Ahmad Fauzi Pei, Sean Goh Othman, Mohd. Hafiz Dzarfan Abdullah, Mohd. Sohaimi Be, Cheer Ng Abdul Kadir, Siti Hamimah Sheikh Kamal, Fatmawati |
author_facet |
Said, Noresah Zainol Abidin, Muhammad Nidzhom Hasbullah, Hasrinah Ismail, Ahmad Fauzi Pei, Sean Goh Othman, Mohd. Hafiz Dzarfan Abdullah, Mohd. Sohaimi Be, Cheer Ng Abdul Kadir, Siti Hamimah Sheikh Kamal, Fatmawati |
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Said, Noresah |
title |
Polysulfone hemodialysis membrane incorporated with Fe2O3 for enhanced removal of middle molecular weight uremic toxin |
title_short |
Polysulfone hemodialysis membrane incorporated with Fe2O3 for enhanced removal of middle molecular weight uremic toxin |
title_full |
Polysulfone hemodialysis membrane incorporated with Fe2O3 for enhanced removal of middle molecular weight uremic toxin |
title_fullStr |
Polysulfone hemodialysis membrane incorporated with Fe2O3 for enhanced removal of middle molecular weight uremic toxin |
title_full_unstemmed |
Polysulfone hemodialysis membrane incorporated with Fe2O3 for enhanced removal of middle molecular weight uremic toxin |
title_sort |
polysulfone hemodialysis membrane incorporated with fe2o3 for enhanced removal of middle molecular weight uremic toxin |
publisher |
Penerbit UTM Press |
publishDate |
2020 |
url |
http://eprints.utm.my/id/eprint/85560/1/AhmadFauziIsmail2020_PolysulfoneHemodialysisMembraneIncorporated.pdf http://eprints.utm.my/id/eprint/85560/ https://mjfas.utm.my/index.php/mjfas/article/view/1464 |
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