Fabrication of poly(lactic-co-glycolic acid)/calcium phosphate bone cement composite: synthesization of calcium phosphate from crab shells

• Main Authors: Abdul Hanan, M. R., Nasution, A. K., Hussain, R., Saidin, S.
• Format: Article
• Language: English
• Published: Penerbit UTM Press 2018
• Subjects: QH301 Biology
• Online Access: http://eprints.utm.my/id/eprint/79704/1/SyafiqahSaidin2018_AbricationofPolyLactic-Co-GlycolicAcidCalcium.pdf; http://eprints.utm.my/id/eprint/79704/; http://dx.doi.org/10.11113/jt.v80.11525

Crab shells are waste product, rich with calcium compound. Calcium element is often used as a material for bone scaffold due to its bioactive and biodegradation properties. In this study, calcium phosphate (CaP) nanoparticles were synthesized from crab shells through a wet chemical route. The CaP nanoparticles were then sintered and mixed with poly(lactic-co-glycolic acid) (PLGA) to form a bone cement composite. The mixture was casted in a cylinder shape and it was characterized through ATR-FTIR, XRD, FESEM, contact angle and DSC analyses. The CaP pellet and the CaP/PLGA bone cement composite were then subjected to in vitro simulated body fluid (SBF) bioactivity test. The CaP/PLGA bone cement composite was found to have a composition of crystal CaP and PLGA with a tolerable glass transition state, suitable to be used in a physiological environment. The CaP nanoparticles were agglomerated on the 3D interconnected surface of PLGA. The hydrophobicity of the CaP was increased (66.94%) with the addition of PLGA as a binder matrix where this composite has induced the formation of apatite layer. This bioactive property is crucial in fabricating a bone substitute material as it can promotes cell penetration, attachment and proliferation.