Drug delivery and cytocompatibility of ciprofloxacin loaded gelatin nanofibers-coated Mg alloy

• Main Authors: Bakhsheshi-Rad, H. R., Hadisi, Z., Hamzah, E., Ismail, A. F., Aziz, M., Kashefian, M.
• Format: Article
• Published: Elsevier B.V. 2017
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/76925/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85025088109&doi=10.1016%2fj.matlet.2017.07.072&partnerID=40&md5=59192b2ca088ba08e3b117e46b3158a0

In this study, gelatin-ciprofloxacin (Gel-Cip) nanofibers containing various amounts of Cip (0, 2, 4 and, 8 wt%) were fabricated on the surface of Mg-1Ca alloy via an electrospinning process. Microscopic characterization indicated a porous network structure with fiber diameters in the range of 150–170 nm. Prolonged drug release was attained from Gel-Cip nanofibers coating along with initial rapid drug release of around 20–22% during 12 h, followed by a slow release stage that can effectively control the infection. The incorporation of 2–4 wt% Cip into Gel nanofibers coating significantly increased the antibacterial performance and corrosion resistance of the uncoated Mg-Ca alloy without showing an inhibitory influence on the cytocompatibility characteristic. Hence, it is potentially appropriate as the novel electrospun nanofibers coating material for bone regeneration application.