A simple, selective, and sensitive gas chromatography-mass spectrometry method for the analysis of five process-related impurities in atenolol bulk drug and capsule formulations

• Main Authors: Reddy, A. V. B., Yusop, Z., Jaafar, J., Aris, A., Abdul Majid, Z.
• Format: Article
• Published: Wiley-VCH Verlag 2017
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/76548/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021423151&doi=10.1002%2fjssc.201700252&partnerID=40&md5=16e559685ca8cc509cf5c666ce8bdebb

An extremely sensitive and simple gas chromatography with mass spectrometry method was developed and completely validated for the analysis of five process-related impurities, viz., 4-hydroxy-l-phenylglycine, 4-hydroxyphenylacetonitrile, 4-hydroxyphenylacetic acid, methyl-4-hydroxyphenylacetate, and...