Celastrol attenuates mitochondrial dysfunction and inflammation in palmitate-mediated insulin resistance in C3A hepatocytes

• Main Authors: Abu Bakar, M. H., Sarmidi, M. R., Tan, J. S., Mohamad Rosdi, M. N.
• Format: Article
• Published: Elsevier B.V. 2017
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/76162/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85011284948&doi=10.1016%2fj.ejphar.2017.01.043&partnerID=40&md5=225918aac909be62f8f2e3d838815f72

Accumulating evidence indicates that mitochondrial dysfunction-induced inflammation is among the convergence points for the greatest hallmarks of hepatic insulin resistance. Celastrol, an anti-inflammatory compound from the root of Tripterygium Wilfordii has been reported to mitigate insulin resista...