Antibacterial efficacy of triple-layered poly(Lactic-co-glycolic acid)/nanoapatite/ lauric acid guided bone regeneration membrane on periodontal bacteria
A guided bone regeneration (GBR) membrane has been extensively used in the repair and regeneration of damaged periodontal tissues. One of the main challenges of GBR restoration is bacterial colonization on the membrane, constitutes to premature membrane degradation. Therefore, the purpose of this st...
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Japanese Society for Dental Materials and Devices
2017
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my.utm.760802018-05-30T04:19:37Z http://eprints.utm.my/id/eprint/76080/ Antibacterial efficacy of triple-layered poly(Lactic-co-glycolic acid)/nanoapatite/ lauric acid guided bone regeneration membrane on periodontal bacteria Saarani, N. N. Jamuna Thevi, K. Shahab, N. Hermawan, H. Saidin, S. QH Natural history A guided bone regeneration (GBR) membrane has been extensively used in the repair and regeneration of damaged periodontal tissues. One of the main challenges of GBR restoration is bacterial colonization on the membrane, constitutes to premature membrane degradation. Therefore, the purpose of this study was to investigate the antibacterial efficacy of triple-layered GBR membrane composed of poly(lactic-co-glycolic acid) (PLGA), nanoapatite (NAp) and lauric acid (LA) with two types of Gram-negative periodontal bacteria, Fusobacterium nucleatum and Porphyromonas gingivalis through a disc diffusion and bacterial count tests. The membranes exhibited a pattern of growth inhibition and killing effect against both bacteria. The increase in LA concentration tended to increase the bactericidal activities which indicated by higher diameter of inhibition zone and higher antibacterial percentage. It is shown that the incorporation of LA into the GBR membrane has retarded the growth and proliferation of Gram-negative periodontal bacteria for the treatment of periodontal disease. Japanese Society for Dental Materials and Devices 2017 Article PeerReviewed Saarani, N. N. and Jamuna Thevi, K. and Shahab, N. and Hermawan, H. and Saidin, S. (2017) Antibacterial efficacy of triple-layered poly(Lactic-co-glycolic acid)/nanoapatite/ lauric acid guided bone regeneration membrane on periodontal bacteria. Dental Materials Journal, 36 (3). pp. 260-265. ISSN 0287-4547 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020112645&doi=10.4012%2fdmj.2016-177&partnerID=40&md5=fb2738084a51c4c1e3045e5c2d9520f8 |
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QH Natural history Saarani, N. N. Jamuna Thevi, K. Shahab, N. Hermawan, H. Saidin, S. Antibacterial efficacy of triple-layered poly(Lactic-co-glycolic acid)/nanoapatite/ lauric acid guided bone regeneration membrane on periodontal bacteria |
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A guided bone regeneration (GBR) membrane has been extensively used in the repair and regeneration of damaged periodontal tissues. One of the main challenges of GBR restoration is bacterial colonization on the membrane, constitutes to premature membrane degradation. Therefore, the purpose of this study was to investigate the antibacterial efficacy of triple-layered GBR membrane composed of poly(lactic-co-glycolic acid) (PLGA), nanoapatite (NAp) and lauric acid (LA) with two types of Gram-negative periodontal bacteria, Fusobacterium nucleatum and Porphyromonas gingivalis through a disc diffusion and bacterial count tests. The membranes exhibited a pattern of growth inhibition and killing effect against both bacteria. The increase in LA concentration tended to increase the bactericidal activities which indicated by higher diameter of inhibition zone and higher antibacterial percentage. It is shown that the incorporation of LA into the GBR membrane has retarded the growth and proliferation of Gram-negative periodontal bacteria for the treatment of periodontal disease. |
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Article |
author |
Saarani, N. N. Jamuna Thevi, K. Shahab, N. Hermawan, H. Saidin, S. |
author_facet |
Saarani, N. N. Jamuna Thevi, K. Shahab, N. Hermawan, H. Saidin, S. |
author_sort |
Saarani, N. N. |
title |
Antibacterial efficacy of triple-layered poly(Lactic-co-glycolic acid)/nanoapatite/ lauric acid guided bone regeneration membrane on periodontal bacteria |
title_short |
Antibacterial efficacy of triple-layered poly(Lactic-co-glycolic acid)/nanoapatite/ lauric acid guided bone regeneration membrane on periodontal bacteria |
title_full |
Antibacterial efficacy of triple-layered poly(Lactic-co-glycolic acid)/nanoapatite/ lauric acid guided bone regeneration membrane on periodontal bacteria |
title_fullStr |
Antibacterial efficacy of triple-layered poly(Lactic-co-glycolic acid)/nanoapatite/ lauric acid guided bone regeneration membrane on periodontal bacteria |
title_full_unstemmed |
Antibacterial efficacy of triple-layered poly(Lactic-co-glycolic acid)/nanoapatite/ lauric acid guided bone regeneration membrane on periodontal bacteria |
title_sort |
antibacterial efficacy of triple-layered poly(lactic-co-glycolic acid)/nanoapatite/ lauric acid guided bone regeneration membrane on periodontal bacteria |
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Japanese Society for Dental Materials and Devices |
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2017 |
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http://eprints.utm.my/id/eprint/76080/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85020112645&doi=10.4012%2fdmj.2016-177&partnerID=40&md5=fb2738084a51c4c1e3045e5c2d9520f8 |
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