Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria
Eugenia caryophyllata L. and Cinnamomum zeylanicum Blume essential oils offer great potential against the pathogens of oral cavity. Both of these essential oils have recently being used as antibiotics and antiviral agents. This study investigates the synergistic effect of E. caryophyllata and C. zey...
Saved in:
Main Authors: | , , , , , |
---|---|
Format: | Article |
Published: |
Italian Association of Chemical Engineering - AIDIC
2017
|
Subjects: | |
Online Access: | http://eprints.utm.my/id/eprint/75770/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019470108&doi=10.3303%2fCET1756239&partnerID=40&md5=afc50145874f97d6163fd2a27970f56a |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.utm.75770 |
---|---|
record_format |
eprints |
spelling |
my.utm.757702018-04-30T13:16:39Z http://eprints.utm.my/id/eprint/75770/ Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria Zainol, S. N. Mohd. Said, S. Abidin, Z. Z. Azizan, N. Majid, F. A. A. Jantan, I. TP Chemical technology Eugenia caryophyllata L. and Cinnamomum zeylanicum Blume essential oils offer great potential against the pathogens of oral cavity. Both of these essential oils have recently being used as antibiotics and antiviral agents. This study investigates the synergistic effect of E. caryophyllata and C. zeylanicum oils against known resistant bacteria in oral infection namely Enterococcus faecalis, Aggregatibacter actinomycetemcomitans, Streptococcus mutan and Streptococcus salivarius. The combination effect E. caryophyllata and C. zeylanicum were evaluated using checkerboard assays. Amoxicillin at concentration 0.1 mg/mL was used as positive control while each bacteria suspension (105 CFU/mL) was used as negative control. The minimum inhibitory concentration (MIC) and fractional inhibitory concentration index (FIC) were calculated to characterised interaction between the combinations. Both E. caryophyllata and C. zeylanicum oils possess antimicrobial activity against all the four bacteria when used on its own or in combination. In combination, the MIC values were reduced for all bacteria compared when in single form. The synergistic antibacterial effect was significant toward E. faecalis, A. actinomycetemcomitans and S. mutans with FIC index is 0.5 and below. Partial synergy was produced in S.salivarus. The acceptable range for synergistic effect is between 0.16 mg/mL and 0.31 mg/mL. Above from 0.63 mg/mL are considered as additive and antagonistic effect. The combinations of these essential oils gave a stronger antibacterial activity and directly can replace the common use of antibiotics like Amoxicillin. This finding suggests a potential therapeutic benefit using the combination of E. caryophyllata and C. zeylanicum oils in the future management of oral infection. Italian Association of Chemical Engineering - AIDIC 2017 Article PeerReviewed Zainol, S. N. and Mohd. Said, S. and Abidin, Z. Z. and Azizan, N. and Majid, F. A. A. and Jantan, I. (2017) Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria. Chemical Engineering Transactions, 56 . pp. 1429-1434. ISSN 2283-9216 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019470108&doi=10.3303%2fCET1756239&partnerID=40&md5=afc50145874f97d6163fd2a27970f56a |
institution |
Universiti Teknologi Malaysia |
building |
UTM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Teknologi Malaysia |
content_source |
UTM Institutional Repository |
url_provider |
http://eprints.utm.my/ |
topic |
TP Chemical technology |
spellingShingle |
TP Chemical technology Zainol, S. N. Mohd. Said, S. Abidin, Z. Z. Azizan, N. Majid, F. A. A. Jantan, I. Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria |
description |
Eugenia caryophyllata L. and Cinnamomum zeylanicum Blume essential oils offer great potential against the pathogens of oral cavity. Both of these essential oils have recently being used as antibiotics and antiviral agents. This study investigates the synergistic effect of E. caryophyllata and C. zeylanicum oils against known resistant bacteria in oral infection namely Enterococcus faecalis, Aggregatibacter actinomycetemcomitans, Streptococcus mutan and Streptococcus salivarius. The combination effect E. caryophyllata and C. zeylanicum were evaluated using checkerboard assays. Amoxicillin at concentration 0.1 mg/mL was used as positive control while each bacteria suspension (105 CFU/mL) was used as negative control. The minimum inhibitory concentration (MIC) and fractional inhibitory concentration index (FIC) were calculated to characterised interaction between the combinations. Both E. caryophyllata and C. zeylanicum oils possess antimicrobial activity against all the four bacteria when used on its own or in combination. In combination, the MIC values were reduced for all bacteria compared when in single form. The synergistic antibacterial effect was significant toward E. faecalis, A. actinomycetemcomitans and S. mutans with FIC index is 0.5 and below. Partial synergy was produced in S.salivarus. The acceptable range for synergistic effect is between 0.16 mg/mL and 0.31 mg/mL. Above from 0.63 mg/mL are considered as additive and antagonistic effect. The combinations of these essential oils gave a stronger antibacterial activity and directly can replace the common use of antibiotics like Amoxicillin. This finding suggests a potential therapeutic benefit using the combination of E. caryophyllata and C. zeylanicum oils in the future management of oral infection. |
format |
Article |
author |
Zainol, S. N. Mohd. Said, S. Abidin, Z. Z. Azizan, N. Majid, F. A. A. Jantan, I. |
author_facet |
Zainol, S. N. Mohd. Said, S. Abidin, Z. Z. Azizan, N. Majid, F. A. A. Jantan, I. |
author_sort |
Zainol, S. N. |
title |
Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria |
title_short |
Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria |
title_full |
Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria |
title_fullStr |
Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria |
title_full_unstemmed |
Synergistic benefit of eugenia caryophyllata L. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria |
title_sort |
synergistic benefit of eugenia caryophyllata l. and cinnamomum zeylanicum blume essential oils against oral pathogenic bacteria |
publisher |
Italian Association of Chemical Engineering - AIDIC |
publishDate |
2017 |
url |
http://eprints.utm.my/id/eprint/75770/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019470108&doi=10.3303%2fCET1756239&partnerID=40&md5=afc50145874f97d6163fd2a27970f56a |
_version_ |
1643657155439493120 |
score |
13.19449 |