Synthesis and study of anti-HIV-1 RT activity of 5-benzoyl-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one derivatives

• Main Authors: Chander, S., Tang, C. R., Al Maqtari, H. M., Jamalis, J., Penta, A., Hadda, T. B., Sirat, H. M., Zheng, Y. T., Sankaranarayanan, M.
• Format: Article
• Published: Academic Press Inc. 2017
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/75438/; https://dx.doi.org/10.1016/j.bioorg.2017.03.013

In the present study, a series of fourteen 5-benzoyl-4-methyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-one derivatives were designed, synthesized and characterized by appropriate spectral analysis. Further, titled compounds were in-vitro screened against wild HIV-1 RT enzyme using ELISA based color...