Synthesis, characterization and in vitro evaluation of exquisite targeting SPIONs-PEG-HER in HER2+ human breast cancer cells

• Main Authors: Almaki, Javad Hamzehalipour, Nasiri, Rozita, Idris, Ani, Abdul Majid, Fadzilah Adibah, Salouti, Mojtaba, Wong, Tet Soon, Dabagh, Shadab, Marvibaigi, Mohsen, Amini, Neda
• Format: Article
• Published: Institute of Physics Publishing 2016
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/73869/; https://www.scopus.com/inward/record.uri?eid=2-s2.0-84958191559&doi=10.1088%2f0957-4484%2f27%2f10%2f105601&partnerID=40&md5=69cc9aa124b2d0b180c767d71a40d455

A stable, biocompatible and exquisite SPIONs-PEG-HER targeting complex was developed. Initially synthesized superparamagnetic iron oxide nanoparticles (SPIONs) were silanized using 3-aminopropyltrimethoxysilane (APS) as the coupling agent in order to allow the covalent bonding of polyethylene glycol...