Beyond classical meta-analysis: Can inadequately reported studies be included?
Classical meta-analysis requires the same data from each clinical trial, thus data-reporting must be of a high-quality. Imputation methods are used to include studies that provide incomplete information on variability and the fixed and random effects of a drug. Regression models can be used to inclu...
Saved in:
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2004
|
Online Access: | http://eprints.utm.my/id/eprint/7379/1/Nik_Rumzi_Nik_Idris_2004_Beyond_Classical_Meta-analysis.pdf http://eprints.utm.my/id/eprint/7379/ http://dx.doi.org/10.1016/S1359-6446(04)03274-X |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.utm.7379 |
---|---|
record_format |
eprints |
spelling |
my.utm.73792010-06-01T15:51:39Z http://eprints.utm.my/id/eprint/7379/ Beyond classical meta-analysis: Can inadequately reported studies be included? Robertson, Chris Nik Idris, Nik Ruzni Boyle, Peter Classical meta-analysis requires the same data from each clinical trial, thus data-reporting must be of a high-quality. Imputation methods are used to include studies that provide incomplete information on variability and the fixed and random effects of a drug. Regression models can be used to include studies other than randomized placebo-controlled studies. In the example outlined here, the use of non-randomized single-arm studies and studies against comparator treatments has little influence on the estimation of the treatment effect in comparison with placebo, an effect that is based on the randomized placebo-controlled studies. The inclusion of other studies serves to increase the precision of the effect of the treatment compared with baseline. Although multiple imputation techniques enable a larger number of studies to be included, which will typically increase the precision of the estimated effect, a careful sensitivity analysis is also required. Elsevier 2004-11-01 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/7379/1/Nik_Rumzi_Nik_Idris_2004_Beyond_Classical_Meta-analysis.pdf Robertson, Chris and Nik Idris, Nik Ruzni and Boyle, Peter (2004) Beyond classical meta-analysis: Can inadequately reported studies be included? Drug Discovery Today, 9 (21). pp. 924-931. ISSN 1359-6446 http://dx.doi.org/10.1016/S1359-6446(04)03274-X 10.1016/S1359-6446(04)03274-X |
institution |
Universiti Teknologi Malaysia |
building |
UTM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Teknologi Malaysia |
content_source |
UTM Institutional Repository |
url_provider |
http://eprints.utm.my/ |
language |
English |
description |
Classical meta-analysis requires the same data from each clinical trial, thus data-reporting must be of a high-quality. Imputation methods are used to include studies that provide incomplete information on variability and the fixed and random effects of a drug. Regression models can be used to include studies other than randomized placebo-controlled studies. In the example outlined here, the use of non-randomized single-arm studies and studies against comparator treatments has little influence on the estimation of the treatment effect in comparison with placebo, an effect that is based on the randomized placebo-controlled studies. The inclusion of other studies serves to increase the precision of the effect of the treatment compared with baseline. Although multiple imputation techniques enable a larger number of studies to be included, which will typically increase the precision of the estimated effect, a careful sensitivity analysis is also required. |
format |
Article |
author |
Robertson, Chris Nik Idris, Nik Ruzni Boyle, Peter |
spellingShingle |
Robertson, Chris Nik Idris, Nik Ruzni Boyle, Peter Beyond classical meta-analysis: Can inadequately reported studies be included? |
author_facet |
Robertson, Chris Nik Idris, Nik Ruzni Boyle, Peter |
author_sort |
Robertson, Chris |
title |
Beyond classical meta-analysis: Can inadequately reported studies be included? |
title_short |
Beyond classical meta-analysis: Can inadequately reported studies be included? |
title_full |
Beyond classical meta-analysis: Can inadequately reported studies be included? |
title_fullStr |
Beyond classical meta-analysis: Can inadequately reported studies be included? |
title_full_unstemmed |
Beyond classical meta-analysis: Can inadequately reported studies be included? |
title_sort |
beyond classical meta-analysis: can inadequately reported studies be included? |
publisher |
Elsevier |
publishDate |
2004 |
url |
http://eprints.utm.my/id/eprint/7379/1/Nik_Rumzi_Nik_Idris_2004_Beyond_Classical_Meta-analysis.pdf http://eprints.utm.my/id/eprint/7379/ http://dx.doi.org/10.1016/S1359-6446(04)03274-X |
_version_ |
1643644760811896832 |
score |
13.188404 |