A model of the mechanical degradation of foam replicated scaffolds

Tissue engineering scaffolds are implants that actively support tissue growth whilst providing mechanical support. For optimum functionality, they are designed to slowly dissolve in vivo so that no foreign material remains permanently implanted inside the body. The current study uses a simple degrad...

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Main Authors: Sulong, Mohd. Ayub, Belova, I. V., Boccaccini, A. R., Murch, G. E., Fiedler, T.
Format: Article
Published: Springer New York LLC 2016
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Online Access:http://eprints.utm.my/id/eprint/72745/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955672692&doi=10.1007%2fs10853-015-9701-x&partnerID=40&md5=1c4d31a6f0f823aa2a9a2373054162af
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spelling my.utm.727452017-11-27T09:02:13Z http://eprints.utm.my/id/eprint/72745/ A model of the mechanical degradation of foam replicated scaffolds Sulong, Mohd. Ayub Belova, I. V. Boccaccini, A. R. Murch, G. E. Fiedler, T. TJ Mechanical engineering and machinery Tissue engineering scaffolds are implants that actively support tissue growth whilst providing mechanical support. For optimum functionality, they are designed to slowly dissolve in vivo so that no foreign material remains permanently implanted inside the body. The current study uses a simple degradation model that estimates the change of scaffold geometry due to surface erosion. This model is applied on scaffolds that have been manufactured using the foam replication method. In order to capture their complex geometry, micro-computed tomography scans of samples are obtained. Their change in geometry and degradation of mechanical properties is evaluated using computational analysis. The present investigation found that the mechanical properties such as the quasi-elastic gradient, 0.2 % offset yield stress and the plateau stress are decreased systematically over a 10-week period of immersion time. Deformation analysis on the titania foam scaffold is performed by means of the deformed model obtained from finite element calculations. Springer New York LLC 2016 Article PeerReviewed Sulong, Mohd. Ayub and Belova, I. V. and Boccaccini, A. R. and Murch, G. E. and Fiedler, T. (2016) A model of the mechanical degradation of foam replicated scaffolds. Journal of Materials Science, 51 (8). pp. 3824-3835. ISSN 0022-2461 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955672692&doi=10.1007%2fs10853-015-9701-x&partnerID=40&md5=1c4d31a6f0f823aa2a9a2373054162af
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TJ Mechanical engineering and machinery
spellingShingle TJ Mechanical engineering and machinery
Sulong, Mohd. Ayub
Belova, I. V.
Boccaccini, A. R.
Murch, G. E.
Fiedler, T.
A model of the mechanical degradation of foam replicated scaffolds
description Tissue engineering scaffolds are implants that actively support tissue growth whilst providing mechanical support. For optimum functionality, they are designed to slowly dissolve in vivo so that no foreign material remains permanently implanted inside the body. The current study uses a simple degradation model that estimates the change of scaffold geometry due to surface erosion. This model is applied on scaffolds that have been manufactured using the foam replication method. In order to capture their complex geometry, micro-computed tomography scans of samples are obtained. Their change in geometry and degradation of mechanical properties is evaluated using computational analysis. The present investigation found that the mechanical properties such as the quasi-elastic gradient, 0.2 % offset yield stress and the plateau stress are decreased systematically over a 10-week period of immersion time. Deformation analysis on the titania foam scaffold is performed by means of the deformed model obtained from finite element calculations.
format Article
author Sulong, Mohd. Ayub
Belova, I. V.
Boccaccini, A. R.
Murch, G. E.
Fiedler, T.
author_facet Sulong, Mohd. Ayub
Belova, I. V.
Boccaccini, A. R.
Murch, G. E.
Fiedler, T.
author_sort Sulong, Mohd. Ayub
title A model of the mechanical degradation of foam replicated scaffolds
title_short A model of the mechanical degradation of foam replicated scaffolds
title_full A model of the mechanical degradation of foam replicated scaffolds
title_fullStr A model of the mechanical degradation of foam replicated scaffolds
title_full_unstemmed A model of the mechanical degradation of foam replicated scaffolds
title_sort model of the mechanical degradation of foam replicated scaffolds
publisher Springer New York LLC
publishDate 2016
url http://eprints.utm.my/id/eprint/72745/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955672692&doi=10.1007%2fs10853-015-9701-x&partnerID=40&md5=1c4d31a6f0f823aa2a9a2373054162af
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score 13.214268