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Beilschglabrines A and B: two new bioactive phenanthrene alkaloids from the stem bark of Beilschmiedia glabra

Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis...

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Bibliographic Details
Main Authors: Salleh, W. M. N. H. W., Ahmad, F., Khong, H. Y., Zulkifli, R. M., Chen, J. J., Nahar, L., Wansi, J. D., Sarker, S. D.
Format: Article
Published: Elsevier Ltd 2016
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/72504/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964659720&doi=10.1016%2fj.phytol.2016.04.013&partnerID=40&md5=a2975f6d81f2211ef8bf44d5de8f5799
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Summary:Two new phenanthrene alkaloids, beilschglabrines A (1) and B (2) were isolated from the stem bark of Beilschmiedia glabra, together with lupeol, taraxerol, and 24-methylenelanosta-7,9-diene-3β-15α-diol. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for DPPH radical scavenging, acetylcholinesterase and lipoxygenase inhibitory activities. Compound 1 displayed considerable activity in the acetylcholinesterase (IC50 50.4 μM), the DPPH radical scavenging (IC50 115.9 μM) and the lipoxygenase (IC50 32.8 μM) assays.

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