Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and Carica papaya extract for the management of burn injuries
Management of burn injury is an onerous clinical task since it requires continuous monitoring and extensive usage of specialized facilities. Despite rapid improvizations and investments in burn management, >30% of victims hospitalized each year face severe morbidity and mortality. Excessive loss...
Saved in:
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Dove Medical Press Ltd.
2016
|
Subjects: | |
Online Access: | http://eprints.utm.my/id/eprint/72103/1/AhmadFauziIsmail2016_FabricationandHemocompatibilityAssessmentofNovel.pdf http://eprints.utm.my/id/eprint/72103/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988888107&doi=10.2147%2fIJN.S112265&partnerID=40&md5=474f0bfb057e852c6af7bb1fbc02305e |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.utm.72103 |
---|---|
record_format |
eprints |
spelling |
my.utm.721032017-11-23T06:19:25Z http://eprints.utm.my/id/eprint/72103/ Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and Carica papaya extract for the management of burn injuries Balaji, A. Jaganathan, S. K. Ismail, A. F. Rajasekar, R. TP Chemical technology Management of burn injury is an onerous clinical task since it requires continuous monitoring and extensive usage of specialized facilities. Despite rapid improvizations and investments in burn management, >30% of victims hospitalized each year face severe morbidity and mortality. Excessive loss of body fluids, accumulation of exudate, and the development of septic shock are reported to be the main reasons for morbidity in burn victims. To assist burn wound management, a novel polyurethane (PU)-based bio-nanofibrous dressing loaded with honey (HN) and Carica papaya (PA) fruit extract was fabricated using a one-step electrospinning technique. The developed dressing material had a mean fiber diameter of 190±19.93 nm with pore sizes of 4-50 µm to support effective infiltration of nutrients and gas exchange. The successful blending of HN- and PA-based active biomolecules in PU was inferred through changes in surface chemistry. The blend subsequently increased the wettability (14%) and surface energy (24%) of the novel dressing. Ultimately, the presence of hydrophilic biomolecules and high porosity enhanced the water absorption ability of the PU-HN-PA nanofiber samples to 761.67% from 285.13% in PU. Furthermore, the ability of the bio-nanofibrous dressing to support specific protein adsorption (45%), delay thrombus formation, and reduce hemolysis demonstrated its nontoxic and compatible nature with the host tissues. In summary, the excellent physicochemical and hemocompatible properties of the developed PU-HN-PA dressing exhibit its potential in reducing the clinical complications associated with the treatment of burn injuries. Dove Medical Press Ltd. 2016 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/72103/1/AhmadFauziIsmail2016_FabricationandHemocompatibilityAssessmentofNovel.pdf Balaji, A. and Jaganathan, S. K. and Ismail, A. F. and Rajasekar, R. (2016) Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and Carica papaya extract for the management of burn injuries. International Journal of Nanomedicine, 11 . pp. 4339-4355. ISSN 1176-9114 https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988888107&doi=10.2147%2fIJN.S112265&partnerID=40&md5=474f0bfb057e852c6af7bb1fbc02305e |
institution |
Universiti Teknologi Malaysia |
building |
UTM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Teknologi Malaysia |
content_source |
UTM Institutional Repository |
url_provider |
http://eprints.utm.my/ |
language |
English |
topic |
TP Chemical technology |
spellingShingle |
TP Chemical technology Balaji, A. Jaganathan, S. K. Ismail, A. F. Rajasekar, R. Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and Carica papaya extract for the management of burn injuries |
description |
Management of burn injury is an onerous clinical task since it requires continuous monitoring and extensive usage of specialized facilities. Despite rapid improvizations and investments in burn management, >30% of victims hospitalized each year face severe morbidity and mortality. Excessive loss of body fluids, accumulation of exudate, and the development of septic shock are reported to be the main reasons for morbidity in burn victims. To assist burn wound management, a novel polyurethane (PU)-based bio-nanofibrous dressing loaded with honey (HN) and Carica papaya (PA) fruit extract was fabricated using a one-step electrospinning technique. The developed dressing material had a mean fiber diameter of 190±19.93 nm with pore sizes of 4-50 µm to support effective infiltration of nutrients and gas exchange. The successful blending of HN- and PA-based active biomolecules in PU was inferred through changes in surface chemistry. The blend subsequently increased the wettability (14%) and surface energy (24%) of the novel dressing. Ultimately, the presence of hydrophilic biomolecules and high porosity enhanced the water absorption ability of the PU-HN-PA nanofiber samples to 761.67% from 285.13% in PU. Furthermore, the ability of the bio-nanofibrous dressing to support specific protein adsorption (45%), delay thrombus formation, and reduce hemolysis demonstrated its nontoxic and compatible nature with the host tissues. In summary, the excellent physicochemical and hemocompatible properties of the developed PU-HN-PA dressing exhibit its potential in reducing the clinical complications associated with the treatment of burn injuries. |
format |
Article |
author |
Balaji, A. Jaganathan, S. K. Ismail, A. F. Rajasekar, R. |
author_facet |
Balaji, A. Jaganathan, S. K. Ismail, A. F. Rajasekar, R. |
author_sort |
Balaji, A. |
title |
Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and Carica papaya extract for the management of burn injuries |
title_short |
Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and Carica papaya extract for the management of burn injuries |
title_full |
Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and Carica papaya extract for the management of burn injuries |
title_fullStr |
Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and Carica papaya extract for the management of burn injuries |
title_full_unstemmed |
Fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and Carica papaya extract for the management of burn injuries |
title_sort |
fabrication and hemocompatibility assessment of novel polyurethane-based bio-nanofibrous dressing loaded with honey and carica papaya extract for the management of burn injuries |
publisher |
Dove Medical Press Ltd. |
publishDate |
2016 |
url |
http://eprints.utm.my/id/eprint/72103/1/AhmadFauziIsmail2016_FabricationandHemocompatibilityAssessmentofNovel.pdf http://eprints.utm.my/id/eprint/72103/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988888107&doi=10.2147%2fIJN.S112265&partnerID=40&md5=474f0bfb057e852c6af7bb1fbc02305e |
_version_ |
1643656357635686400 |
score |
13.18916 |