Anticholinesterase and anti-inflammatory constituents from beilschmiedia pulverulenta kosterm
Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin ( 1 ), (+)-sesartemin ( 2 ), (+)-excelsin ( 3 ), (+)-sesamin ( 4 ), and (+)-syringaresinol ( 5 ), together with lupeol ( 6 ), lupenone ( 7 ), β -sitosterol ( 8 ),...
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Korean Society Of Pharmacognosy
2016
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my.utm.683052017-11-20T08:52:05Z http://eprints.utm.my/id/eprint/68305/ Anticholinesterase and anti-inflammatory constituents from beilschmiedia pulverulenta kosterm W. Salleh, Wan Mohd Nuzul Hakimi Ahmad, Farediah Khong, Heng Yen Mohamed Zulkifli, Razauden Q Science R Medicine Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin ( 1 ), (+)-sesartemin ( 2 ), (+)-excelsin ( 3 ), (+)-sesamin ( 4 ), and (+)-syringaresinol ( 5 ), together with lupeol ( 6 ), lupenone ( 7 ), β -sitosterol ( 8 ), and β -sitostenone ( 9 ). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. The isolated lignans were tested for their anticholinesterase (AChE: acetylcholine esterase and BChE: butyryl cholineesterase) and anti-inflammatory (COX-2: cyclooxygenase-2 and LOX: lipoxygenase) activities. All the isolated lignans ( 1 – 5 ) exhibited significant inhibition activities in AChE/BChE and COX-2/LOX assays with IC 50 values ranging from 168.8 – 504.2 μM and 21.0 – 59.4 μM, respectively. Korean Society Of Pharmacognosy 2016-01-12 Article PeerReviewed W. Salleh, Wan Mohd Nuzul Hakimi and Ahmad, Farediah and Khong, Heng Yen and Mohamed Zulkifli, Razauden (2016) Anticholinesterase and anti-inflammatory constituents from beilschmiedia pulverulenta kosterm. Natural Product Sciences, 22 (4). pp. 225-230. ISSN 1226-3907 https://doi.org/10.20307/nps.2016.22.4.1 |
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Q Science R Medicine W. Salleh, Wan Mohd Nuzul Hakimi Ahmad, Farediah Khong, Heng Yen Mohamed Zulkifli, Razauden Anticholinesterase and anti-inflammatory constituents from beilschmiedia pulverulenta kosterm |
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Phytochemical investigation from the stem bark of Beilschmiedia pulverulenta resulted in the isolation of five lignans, (+)-yangambin ( 1 ), (+)-sesartemin ( 2 ), (+)-excelsin ( 3 ), (+)-sesamin ( 4 ), and (+)-syringaresinol ( 5 ), together with lupeol ( 6 ), lupenone ( 7 ), β -sitosterol ( 8 ), and β -sitostenone ( 9 ). Their structures were established by the analysis of their spectroscopic (1D and 2D NMR) and spectrometric (MS) data, as well as by comparison with those reported in the literature. The isolated lignans were tested for their anticholinesterase (AChE: acetylcholine esterase and BChE: butyryl cholineesterase) and anti-inflammatory (COX-2: cyclooxygenase-2 and LOX: lipoxygenase) activities. All the isolated lignans ( 1 – 5 ) exhibited significant inhibition activities in AChE/BChE and COX-2/LOX assays with IC 50 values ranging from 168.8 – 504.2 μM and 21.0 – 59.4 μM, respectively. |
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W. Salleh, Wan Mohd Nuzul Hakimi Ahmad, Farediah Khong, Heng Yen Mohamed Zulkifli, Razauden |
author_facet |
W. Salleh, Wan Mohd Nuzul Hakimi Ahmad, Farediah Khong, Heng Yen Mohamed Zulkifli, Razauden |
author_sort |
W. Salleh, Wan Mohd Nuzul Hakimi |
title |
Anticholinesterase and anti-inflammatory constituents from beilschmiedia pulverulenta kosterm |
title_short |
Anticholinesterase and anti-inflammatory constituents from beilschmiedia pulverulenta kosterm |
title_full |
Anticholinesterase and anti-inflammatory constituents from beilschmiedia pulverulenta kosterm |
title_fullStr |
Anticholinesterase and anti-inflammatory constituents from beilschmiedia pulverulenta kosterm |
title_full_unstemmed |
Anticholinesterase and anti-inflammatory constituents from beilschmiedia pulverulenta kosterm |
title_sort |
anticholinesterase and anti-inflammatory constituents from beilschmiedia pulverulenta kosterm |
publisher |
Korean Society Of Pharmacognosy |
publishDate |
2016 |
url |
http://eprints.utm.my/id/eprint/68305/ https://doi.org/10.20307/nps.2016.22.4.1 |
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1643655933192044544 |
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13.160551 |