Mathematical modeling of subthreshold resonant properties in pyloric dilator neurons
Various types of neurons exhibit subthreshold resonance oscillation (preferred frequency response) to fluctuating sinusoidal input currents. This phenomenon is well known to influence the synaptic plasticity and frequency of neural network oscillation. This study evaluates the resonant properties of...
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my.utm.585062021-12-16T11:31:59Z http://eprints.utm.my/id/eprint/58506/ Mathematical modeling of subthreshold resonant properties in pyloric dilator neurons Ghaffari, Babak Vazifehkhah Kouhnavard, Mojgan Aihara, Takeshi Kitajima, Tatsuo T Technology (General) Various types of neurons exhibit subthreshold resonance oscillation (preferred frequency response) to fluctuating sinusoidal input currents. This phenomenon is well known to influence the synaptic plasticity and frequency of neural network oscillation. This study evaluates the resonant properties of pacemaker pyloric dilator (PD) neurons in the central pattern generator network through mathematical modeling. From the pharmacological point of view, calcium currents cannot be blocked in PD neurons without removing the calcium-dependent potassium current. Thus, the effects of calcium I Ca and calcium-dependent potassium I KCa currents on resonant properties remain unclear. By taking advantage of Hodgkin-Huxley-type model of neuron and its equivalent RLC circuit, we examine the effects of changing resting membrane potential and those ionic currents on the resonance. Results show that changing the resting membrane potential influences the amplitude and frequency of resonance so that the strength of resonance (Q-value) increases by both depolarization and hyperpolarization of the resting membrane potential. Moreover, hyperpolarization-activated inward current I h and I Ca (in association with I KCa) are dominant factors on resonant properties at hyperpolarized and depolarized potentials, respectively. Through mathematical analysis, results indicate that I h and I KCa affect the resonant properties of PD neurons. However, I Ca only has an amplifying effect on the resonance amplitude of these neurons. Hindawi Publishing Corporation 2015 Article PeerReviewed application/pdf en http://eprints.utm.my/id/eprint/58506/1/BabakVazifehkhahGhaffari2015_MathematicalModelingofSubthresholdResonantProperties.pdf Ghaffari, Babak Vazifehkhah and Kouhnavard, Mojgan and Aihara, Takeshi and Kitajima, Tatsuo (2015) Mathematical modeling of subthreshold resonant properties in pyloric dilator neurons. Biomed Research International, 2015 . ISSN 2314-6133 http://dx.doi.org/10.1155/2015/135787 DOI:10.1155/2015/135787 |
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T Technology (General) Ghaffari, Babak Vazifehkhah Kouhnavard, Mojgan Aihara, Takeshi Kitajima, Tatsuo Mathematical modeling of subthreshold resonant properties in pyloric dilator neurons |
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Various types of neurons exhibit subthreshold resonance oscillation (preferred frequency response) to fluctuating sinusoidal input currents. This phenomenon is well known to influence the synaptic plasticity and frequency of neural network oscillation. This study evaluates the resonant properties of pacemaker pyloric dilator (PD) neurons in the central pattern generator network through mathematical modeling. From the pharmacological point of view, calcium currents cannot be blocked in PD neurons without removing the calcium-dependent potassium current. Thus, the effects of calcium I Ca and calcium-dependent potassium I KCa currents on resonant properties remain unclear. By taking advantage of Hodgkin-Huxley-type model of neuron and its equivalent RLC circuit, we examine the effects of changing resting membrane potential and those ionic currents on the resonance. Results show that changing the resting membrane potential influences the amplitude and frequency of resonance so that the strength of resonance (Q-value) increases by both depolarization and hyperpolarization of the resting membrane potential. Moreover, hyperpolarization-activated inward current I h and I Ca (in association with I KCa) are dominant factors on resonant properties at hyperpolarized and depolarized potentials, respectively. Through mathematical analysis, results indicate that I h and I KCa affect the resonant properties of PD neurons. However, I Ca only has an amplifying effect on the resonance amplitude of these neurons. |
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Article |
author |
Ghaffari, Babak Vazifehkhah Kouhnavard, Mojgan Aihara, Takeshi Kitajima, Tatsuo |
author_facet |
Ghaffari, Babak Vazifehkhah Kouhnavard, Mojgan Aihara, Takeshi Kitajima, Tatsuo |
author_sort |
Ghaffari, Babak Vazifehkhah |
title |
Mathematical modeling of subthreshold resonant properties in pyloric dilator neurons |
title_short |
Mathematical modeling of subthreshold resonant properties in pyloric dilator neurons |
title_full |
Mathematical modeling of subthreshold resonant properties in pyloric dilator neurons |
title_fullStr |
Mathematical modeling of subthreshold resonant properties in pyloric dilator neurons |
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Mathematical modeling of subthreshold resonant properties in pyloric dilator neurons |
title_sort |
mathematical modeling of subthreshold resonant properties in pyloric dilator neurons |
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Hindawi Publishing Corporation |
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2015 |
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http://eprints.utm.my/id/eprint/58506/1/BabakVazifehkhahGhaffari2015_MathematicalModelingofSubthresholdResonantProperties.pdf http://eprints.utm.my/id/eprint/58506/ http://dx.doi.org/10.1155/2015/135787 |
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