Development of fed-batch cultivation strategy for efficient oxytetracycline production by streptomyces rimosus at semi-industrial scale

• Main Authors: Elsayed, Elsayed Ahmed, Omar, Hoda Gamal, El-Enshasy, Hesham Ali
• Format: Article
• Language: English
• Published: Instituto de Tecnologia do Parana 2015
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/58292/1/ElsayedAhmedElsayed2015_DevelopmentofFed-BatchCultivationStrategyforEfficientOxytetracycline.pdf; http://eprints.utm.my/id/eprint/58292/; http://dx.doi.org/10.1590/S1516-89132015050184

Oxytetracycline (OTC) production by Streptomyces rimosus was studied in batch and fed-batch cultures in shake flask and bioreactor levels using semi-defined medium. First, the effect of glucose concentration on OTC production and growth kinetics was studied intensively. The optimal glucose concentra...