Antioxidant and anticholinesterase activities of essential oils of cinnamomum griffithii and C. macrocarpum

• Main Authors: Wan Salleh, Wan Mohd. Nuzul Hakimi, Ahmad, Farediah, Yen, Khong Heng
• Format: Article
• Language: English
• Published: Natural Product Incorporation 2015
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/57840/1/WanMohd2015_AntioxidantandAnticholinesteraseActivitiesofEssential.pdf; http://eprints.utm.my/id/eprint/57840/; http://dx.doi.org/10.1177/1934578x1501000838

The essential oils of Cinnamomum griffithii and C. macrocarpum were analyzed by GC and GC-MS and evaluated for their antioxidant and anticholinesterase activities. The essential oils of leaf and bark of C. grffithii were characterized by the presence of 30 components, with methyl eugenol (38.5-43.8%) as the major component. A total of 11 components were characterized in.the leaf and bark of C. macrocarpum essential oil with the most abundant component was safrole (54.5-59.5%). The bark oil of C. griffithii demonstrated significant activity on DPPH (IC50 73.4 microg/mL) and a high phenolic content (192.0%), while the leaf oil inhibited oxidation of β-carotene/linoleic acid with an inhibition value of 65.5 μg/mL. Acetylcholinesterase and butyrylcholinesterase inhibition were assessed and the results showed that C. macrocarpun bark oil exhibited significant activity with inhibition values of 55.8% and 66.1%, respectively at a concentration of 1 mg/mL.