A novel protein interaction between nucleotide binding domain of Hsp70 and p53 motif

• Main Authors: Elengoe, Asita, Naser, Mohammed Abu, Hamdan, Salehhuddin
• Format: Article
• Published: Hindawi Publishing Corporation 2015
• Subjects: QD Chemistry
• Online Access: http://eprints.utm.my/id/eprint/55785/; http://dx.doi.org/10.1155/2015/391293

Currently, protein interaction of Homo sapiens nucleotide binding domain (NBD) of heat shock 70 kDa protein (PDB: 1HJO) with p53 motif remains to be elucidated. The NBD-p53 motif complex enhances the p53 stabilization, thereby increasing the tumor suppression activity in cancer treatment. Therefore,...