1H NMR-based metabolomics investigation of copper-laden rat: a model of Wilson's disease

• Main Authors: Jingjing, Xu, Huaizhou, Jiang, Jinquan, Li, Kian, Kai Cheng, Jiyang, Dong, Zhong, Chen
• Format: Article
• Published: Public Library of Science 2015
• Subjects: TP Chemical technology
• Online Access: http://eprints.utm.my/id/eprint/54925/; http://dx.doi.org/10.1371/journal.pone.0119654

Wilson's disease (WD), also known as hepatoleticular degeneration (HLD), is a rare autosomal recessive genetic disorder of copper metabolism, which causes copper to accumulate in body tissues. In this study, rats fed with copper-laden diet are used to render the clinical manifestations of WD, a...