New preparation method of highly reactive electrogenerated zinc and its use in cross-coupling reaction of functionalized organic bromides with aryl halides by using electrochemical method

• Main Authors: Abdul Jalil, Aishah, Sundang, Murni, Triwahyono, Sugeng, Muhd. Muhid, Muhd. Nazlan, Kurono, Nobuhito, Tokuda, Masao
• Format: Conference or Workshop Item
• Language: English
• Published: 2005
• Subjects: T Technology (General)
• Online Access: http://eprints.utm.my/id/eprint/5244/1/AishahAbdulJalil2005_NewPreparationMethodOfHighlyReactive.pdf; http://eprints.utm.my/id/eprint/5244/

A new highly reactive zinc metal was readily prepared by electrolysis of a DMF solution containing polyaromatic compounds (PA) as a mediator and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This reactive zinc (EGZn/PA) was used for transformation of organic bromides into the corresponding organozinc bromides, which can not be achieved by the use of either reactive zinc (EGZn) or usual zinc metals. Reaction of the organozinc compounds thus prepared with various aryl iodides in the presence of 5 mol% of palladium catalyst gave the corresponding cross-coupling products in high yields. Arylzinc halides were also prepared by the use EGZn/PA, and they were reacted with other aryl halides to give the corresponding cross-coupled biaryl in good yields.