Synthesis of precursor of anti-cancer drugs

• Main Authors: Abdul Jalil, Aishah, Kurono, Nobuhito, Tokuda, Masao
• Format: Conference or Workshop Item
• Language: English
• Published: 2004
• Subjects: T Technology (General)
• Online Access: http://eprints.utm.my/id/eprint/5235/1/AishahAbdulJalil2004_SynthesisOfPrecursorOfAnti-cancerDrugs.pdf; http://eprints.utm.my/id/eprint/5235/

Highly reactive electrogenerated zinc metal (EGZn/Naph) was readily prepared by electrolysis of a DMF solution containing naphthalene and a supporting electrolyte in a one-compartment cell fitted with a platinum cathode and a zinc anode. This reactive zinc was used for efficient transformation of ethyl 2-bromoacrylate into the corresponding organozinc compound, which was reacted with various aryl halides in the presence of palladium catalyst to give the corresponding cross-coupling products, ethyl 2-arylpropenoates, in high yields. These cross-coupling reactions were successfully applied to a synthesis of the precursors of non-steroidal anti-inflammatory drugs such as ibuprofen, ketoprofen and ioxoprofen, which recently, have been shown to decrease the risk of cancer.