Combining multiple clusterings of chemical structures using cluster-based similarity partitioning algorithm
Many types of clustering techniques for chemical structures have been used in the literature, but it is known that any single method will not always give the best results for all types of applications. Recent work on consensus clustering methods is motivated because of the successes of combining mul...
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Inderscience Enterprises Ltd.
2014
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my.utm.521462019-01-28T04:44:58Z http://eprints.utm.my/id/eprint/52146/ Combining multiple clusterings of chemical structures using cluster-based similarity partitioning algorithm Saeed, Faisal Salim, Naomie Abdo, Ammar QA75 Electronic computers. Computer science Many types of clustering techniques for chemical structures have been used in the literature, but it is known that any single method will not always give the best results for all types of applications. Recent work on consensus clustering methods is motivated because of the successes of combining multiple classifiers in many areas and the ability of consensus clustering to improve the robustness, novelty, consistency and stability of individual clusterings. In this paper, the Cluster-based Similarity Partitioning Algorithm (CSPA) was examined for improving the quality of chemical structures clustering. The effectiveness of clustering was evaluated based on the ability to separate active from inactive molecules in each cluster and the results were compared with the Ward's clustering method. The chemical dataset MDL Drug Data Report (MDDR) database was used for experiments. The results, obtained by combining multiple clusterings, showed that the consensus clustering method can improve the robustness, novelty and stability of chemical structures clustering. Inderscience Enterprises Ltd. 2014 Article PeerReviewed Saeed, Faisal and Salim, Naomie and Abdo, Ammar (2014) Combining multiple clusterings of chemical structures using cluster-based similarity partitioning algorithm. International Journal of Computational Biology and Drug Design, 7 (1). pp. 31-44. ISSN 1756-0756 http://dx.doi.org/10.1504/IJCBDD.2014.058584 DOI: 10.1504/IJCBDD.2014.058584 |
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QA75 Electronic computers. Computer science Saeed, Faisal Salim, Naomie Abdo, Ammar Combining multiple clusterings of chemical structures using cluster-based similarity partitioning algorithm |
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Many types of clustering techniques for chemical structures have been used in the literature, but it is known that any single method will not always give the best results for all types of applications. Recent work on consensus clustering methods is motivated because of the successes of combining multiple classifiers in many areas and the ability of consensus clustering to improve the robustness, novelty, consistency and stability of individual clusterings. In this paper, the Cluster-based Similarity Partitioning Algorithm (CSPA) was examined for improving the quality of chemical structures clustering. The effectiveness of clustering was evaluated based on the ability to separate active from inactive molecules in each cluster and the results were compared with the Ward's clustering method. The chemical dataset MDL Drug Data Report (MDDR) database was used for experiments. The results, obtained by combining multiple clusterings, showed that the consensus clustering method can improve the robustness, novelty and stability of chemical structures clustering. |
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Article |
author |
Saeed, Faisal Salim, Naomie Abdo, Ammar |
author_facet |
Saeed, Faisal Salim, Naomie Abdo, Ammar |
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Saeed, Faisal |
title |
Combining multiple clusterings of chemical structures using cluster-based similarity partitioning algorithm |
title_short |
Combining multiple clusterings of chemical structures using cluster-based similarity partitioning algorithm |
title_full |
Combining multiple clusterings of chemical structures using cluster-based similarity partitioning algorithm |
title_fullStr |
Combining multiple clusterings of chemical structures using cluster-based similarity partitioning algorithm |
title_full_unstemmed |
Combining multiple clusterings of chemical structures using cluster-based similarity partitioning algorithm |
title_sort |
combining multiple clusterings of chemical structures using cluster-based similarity partitioning algorithm |
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Inderscience Enterprises Ltd. |
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2014 |
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http://eprints.utm.my/id/eprint/52146/ http://dx.doi.org/10.1504/IJCBDD.2014.058584 |
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