Contribution of voltage-dependent ion channels to subthreshold resonance
Subthreshold resonance has been observed in many excitatory/'inhibitory neurons in the brain and it is suggested that such resonance phenomena play an important role in behavioral or perceptual functions in animals. Various voltage-dependent channels are thought to be involved in the generation...
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| Main Authors: | , |
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| Format: | Conference or Workshop Item |
| Published: |
2013
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| Subjects: | |
| Online Access: | http://eprints.utm.my/id/eprint/50960/ http://apps.webofknowledge.com.ezproxy.utm.my/full_record.do?product=WOS&search_mode=GeneralSearch&qid=10&SID=N1dkxqVtUFryLiyCtwo&page=1&doc=1 |
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| Summary: | Subthreshold resonance has been observed in many excitatory/'inhibitory neurons in the brain and it is suggested that such resonance phenomena play an important role in behavioral or perceptual functions in animals. Various voltage-dependent channels are thought to be involved in the generation of these resonance oscillations. For a compartmental neuron model with Ca2+-dependent K+ channel and low-threshold Ca2+ channel, conductance-based channel dynamics are linearized around equilibrium states and a neuron model can be treated as an equivalent RLC electric circuit, which indicates that the subthreshold resonance may be attributable to inductive properties of voltage-dependent channels. By computer simulation, we examine how parameters of these voltage-dependent channels, such as an equilibrium potential and the amplitude, effect to generate a subthreshold resonance. |
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