Targeted metabolomics identifies perturbations in amino acid metabolism that sub-classify patients with COPD

• Main Authors: Ubhi, Baljit K., Kian, Kai Cheng, Dong, Jiyang, Janowitz, Tobias, Jodrell, Duncan, Singer, Ruth Tal, MacNee, William, Lomas, David A., Riley, John H., Griffinai, Julian L., Connora, Susan C.
• Format: Article
• Published: The Royal Society of Chemistry 2012
• Subjects: QH301 Biology
• Online Access: http://eprints.utm.my/id/eprint/47581/; http://dx.doi.org/10.1039/c2mb25194a

Background: COPD, a leading cause of mortality is currently assessed by spirometry (forced expiratory volume in 1 second, FEV1). However FEV1 does not correlate with patient mortality. ECLIPSE (Evaluation of Chronic obstructive pulmonary disease to Longitudinally Identify Predictive Surrogate Endpoi...