Reverse micelle liquid-liquid extraction of a pharmaceutical product
Reverse micelle extraction has received considerable attention in recent years due to its ability to selectively solubilise solutes from an aqueous phase, and in the case of biomolecules to maintain their biological activities. The apparent success of research on protein extraction from the aqueous...
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my.utm.474712019-03-05T01:51:32Z http://eprints.utm.my/id/eprint/47471/ Reverse micelle liquid-liquid extraction of a pharmaceutical product Mohd. Setapar, Siti Hamidah Mohamad Aziz, Siti Norazimah Harun, Noor Hafiza Hussin, S. H. TA Engineering (General). Civil engineering (General) Reverse micelle extraction has received considerable attention in recent years due to its ability to selectively solubilise solutes from an aqueous phase, and in the case of biomolecules to maintain their biological activities. The apparent success of research on protein extraction from the aqueous phase using reverse micelle provides motivation to study the solubilisation of antibiotic. The objective of this study is to investigate the extraction of antibiotic (penicillin G is chosen as model antibiotic) from aqueous solution (forward extraction) and from the reverse micelle to a new aqueous solution (backward extraction). Sodium di(2-ethylhexyl)sulfosuccinate (AOT) is chosen as the surfactant and isooctane as the organic solvent. The UV-Vis spectrophotometer is used to determine the mass of penicillin G in solution after the extraction process. The extraction is expected to be influenced by the initial penicillin G concentration, the salt type and concentration in the aqueous phase, pH, and surfactant concentration. It is expected that as penicillin is an interfacially active compound that will interacts with AOT surfactant, the interfacial association will be dependent on both pH and surfactant concentration. Trans Tech Publications 2012 Article PeerReviewed Mohd. Setapar, Siti Hamidah and Mohamad Aziz, Siti Norazimah and Harun, Noor Hafiza and Hussin, S. H. (2012) Reverse micelle liquid-liquid extraction of a pharmaceutical product. Advanced Materials Research, 545 . pp. 240-244. ISSN 1022-6680 http://dx.doi.org/10.4028/www.scientific.net/AMR.545.240 DOI:10.4028/www.scientific.net/AMR.545.240 |
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TA Engineering (General). Civil engineering (General) Mohd. Setapar, Siti Hamidah Mohamad Aziz, Siti Norazimah Harun, Noor Hafiza Hussin, S. H. Reverse micelle liquid-liquid extraction of a pharmaceutical product |
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Reverse micelle extraction has received considerable attention in recent years due to its ability to selectively solubilise solutes from an aqueous phase, and in the case of biomolecules to maintain their biological activities. The apparent success of research on protein extraction from the aqueous phase using reverse micelle provides motivation to study the solubilisation of antibiotic. The objective of this study is to investigate the extraction of antibiotic (penicillin G is chosen as model antibiotic) from aqueous solution (forward extraction) and from the reverse micelle to a new aqueous solution (backward extraction). Sodium di(2-ethylhexyl)sulfosuccinate (AOT) is chosen as the surfactant and isooctane as the organic solvent. The UV-Vis spectrophotometer is used to determine the mass of penicillin G in solution after the extraction process. The extraction is expected to be influenced by the initial penicillin G concentration, the salt type and concentration in the aqueous phase, pH, and surfactant concentration. It is expected that as penicillin is an interfacially active compound that will interacts with AOT surfactant, the interfacial association will be dependent on both pH and surfactant concentration. |
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Article |
author |
Mohd. Setapar, Siti Hamidah Mohamad Aziz, Siti Norazimah Harun, Noor Hafiza Hussin, S. H. |
author_facet |
Mohd. Setapar, Siti Hamidah Mohamad Aziz, Siti Norazimah Harun, Noor Hafiza Hussin, S. H. |
author_sort |
Mohd. Setapar, Siti Hamidah |
title |
Reverse micelle liquid-liquid extraction of a pharmaceutical product |
title_short |
Reverse micelle liquid-liquid extraction of a pharmaceutical product |
title_full |
Reverse micelle liquid-liquid extraction of a pharmaceutical product |
title_fullStr |
Reverse micelle liquid-liquid extraction of a pharmaceutical product |
title_full_unstemmed |
Reverse micelle liquid-liquid extraction of a pharmaceutical product |
title_sort |
reverse micelle liquid-liquid extraction of a pharmaceutical product |
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Trans Tech Publications |
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2012 |
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http://eprints.utm.my/id/eprint/47471/ http://dx.doi.org/10.4028/www.scientific.net/AMR.545.240 |
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1643652323812048896 |
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13.18916 |