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Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent

Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 f...

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Main Authors: Dev, Selvi, Prabhakaran, Praseetha, Filgueira, Luis, Iyer, K. Swaminathan, Raston, Colin L.
Format: Article
Published: The Royal Society of Chemistry 2012
Subjects:
TA Engineering (General). Civil engineering (General)
Online Access:http://eprints.utm.my/id/eprint/47211/
http://dx.doi.org/10.1039/c2nr11502f
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id my.utm.47211
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spelling my.utm.472112019-03-31T08:34:51Z http://eprints.utm.my/id/eprint/47211/ Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent Dev, Selvi Prabhakaran, Praseetha Filgueira, Luis Iyer, K. Swaminathan Raston, Colin L. TA Engineering (General). Civil engineering (General) Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 for up to eight hours. The nanoparticles have enhanced cytotoxicity in estrogens receptor negative and positive breast cancer cell lines compared with free curcumin. The Royal Society of Chemistry 2012 Article PeerReviewed Dev, Selvi and Prabhakaran, Praseetha and Filgueira, Luis and Iyer, K. Swaminathan and Raston, Colin L. (2012) Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent. Nanoscale, 4 (8). pp. 2575-2579. ISSN 2040-3364 http://dx.doi.org/10.1039/c2nr11502f DOI:10.1039/c2nr11502f
institution Universiti Teknologi Malaysia
building UTM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Malaysia
content_source UTM Institutional Repository
url_provider http://eprints.utm.my/
topic TA Engineering (General). Civil engineering (General)
spellingShingle TA Engineering (General). Civil engineering (General)
Dev, Selvi
Prabhakaran, Praseetha
Filgueira, Luis
Iyer, K. Swaminathan
Raston, Colin L.
Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
description Curcumin nanoparticles of less than 50 nm in diameter are accessible using a continuous flow microfluidic rotating tube processor (RTP) under scalable conditions, at room temperature. A mixture of DDAB and Pluronic F127 renders higher stability of the curcumin nanoparticles in physiological pH 7.4 for up to eight hours. The nanoparticles have enhanced cytotoxicity in estrogens receptor negative and positive breast cancer cell lines compared with free curcumin.
format Article
author Dev, Selvi
Prabhakaran, Praseetha
Filgueira, Luis
Iyer, K. Swaminathan
Raston, Colin L.
author_facet Dev, Selvi
Prabhakaran, Praseetha
Filgueira, Luis
Iyer, K. Swaminathan
Raston, Colin L.
author_sort Dev, Selvi
title Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
title_short Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
title_full Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
title_fullStr Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
title_full_unstemmed Microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
title_sort microfluidic fabrication of cationic curcumin nanoparticles as an anti-cancer agent
publisher The Royal Society of Chemistry
publishDate 2012
url http://eprints.utm.my/id/eprint/47211/
http://dx.doi.org/10.1039/c2nr11502f
_version_ 1643652260329160704
score 13.211869

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